biostudies-literatureSato KThe Donald and Joan Wilson FoundationMetro North Hospital and Health ServiceCentre for Research Excellence for Advanced Cardiorespiratory Therapies Improving Organ Support (CRE ACTIONS)The Prince Charles Hospital FoundationUniversity of QueenslandThe National Health and Medical Research CouncilPrince Charles Hospital FoundationThe Alfred FoundationQueensland HealthAdvance Queensland Industry Research FellowshipWellcome TrustThe Metro North Hospital and Health Servicee14259https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616761biostudies-literatureUnknown54(10)<h4>Background</h4>The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload-independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non-invasive echocardiographic parameter, Pressure-Strain Product (PSP), as a potential surrogate of catheter-based LVSWI. This study aimed to investigate if PSP could correlate with catheter-based LVSWI in an ovine model of brain stem death (BSD) donors. The association between PSP and myocardial mitochondrial function in the post-transplant hearts was also evaluated.<h4>Methods</h4>Thirty-one female sheep (weight 47 ± 5 kg) were divided into two groups; BSD (n = 15), and sham neurologic injury (n = 16). Echocardiographic parameters including global circumferential strain (GCS) and global radial strain (GRS) and pulmonary artery catheter-based LVSWI were simultaneously measured at 8-timepoints during 24-h observation. PSP was calculated as a product of GCS or GRS, and mean arterial pressure for PSP_circ or PSP_rad, respectively. Myocardial mitochondrial function was evaluated following 6-h observation after heart transplantation.<h4>Results</h4>In BSD donor hearts, PSP_circ (n = 96, rho = .547, p < .001) showed the best correlation with LVSWI among other echocardiographic parameters. PSP_circ returned AUC of .825 to distinguish higher values of cardiomyocyte mitochondrial function (cut-off point; mean value of complex 1,2 O₂ Flux) in post-transplant hearts, which was greater than other echocardiographic parameters.<h4>Conclusions</h4>PSP_circ could be used as a surrogate of catheter-based LVSWI reflecting mitochondrial function.European journal of clinical investigationEchocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors.PMC7616761227131TM2017‐02TM2017-02RF-04RF‐04GNT1145761 - The Dead Heart ProjectColombo SMSkeggs KWhite NHaymet AObonyo NGFraser JFAbbate GPalmieri CLivingstone SBouquet MHyslop KWildi KChan JMcGiffin DCPassmore MRSuen JYPlatts DHoe LSHeinsar SJung JSBassi GLSato NSato KWilson ESAinola CfalseEchocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors.<h4>Background</h4>The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload-independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non-invasive echocardiographic parameter, Pressure-Strain Product (PSP), as a potential surrogate of catheter-based LVSWI. This study aimed to investigate if PSP could correlate with catheter-based LVSWI in an ovine model of brain stem death (BSD) donors. The association between PSP and myocardial mitochondrial function in the post-transplant hearts was also evaluated.<h4>Methods</h4>Thirty-one female sheep (weight 47 ± 5 kg) were divided into two groups; BSD (n = 15), and sham neurologic injury (n = 16). Echocardiographic parameters including global circumferential strain (GCS) and global radial strain (GRS) and pulmonary artery catheter-based LVSWI were simultaneously measured at 8-timepoints during 24-h observation. PSP was calculated as a product of GCS or GRS, and mean arterial pressure for PSP_circ or PSP_rad, respectively. Myocardial mitochondrial function was evaluated following 6-h observation after heart transplantation.<h4>Results</h4>In BSD donor hearts, PSP_circ (n = 96, rho = .547, p < .001) showed the best correlation with LVSWI among other echocardiographic parameters. PSP_circ returned AUC of .825 to distinguish higher values of cardiomyocyte mitochondrial function (cut-off point; mean value of complex 1,2 O₂ Flux) in post-transplant hearts, which was greater than other echocardiographic parameters.<h4>Conclusions</h4>PSP_circ could be used as a surrogate of catheter-based LVSWI reflecting mitochondrial function.2024-01-01T00:00:00Z2024 Oct2025-04-03T23:23:38.829Z2025-04-03T23:23:38.829ZS-EPMC76167613884511110.1111/eci.14259