{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Couper K"],"funding":["National Institute for Health Research (NIHR)"],"pagination":["336-348"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616768"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["392(4)"],"pubmed_abstract":["Background
In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug administration than an intravenous route; however, its effect on clinical outcomes is uncertain.Methods
We conducted a multicenter, open-label, randomized trial across 11 emergency medical systems in the United Kingdom that involved adults in cardiac arrest for whom vascular access for drug administration was needed. Patients were randomly assigned to receive treatment from paramedics by means of an intraosseous-first or intravenous-first vascular access strategy. The primary outcome was survival at 30 days. Key secondary outcomes included any return of spontaneous circula"],"journal":["The New England journal of medicine"],"pubmed_title":["A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest."],"pmcid":["PMC7616768"],"funding_grant_id":["NIHR131105"],"pubmed_authors":["Williams L","Xanthe C","Wood S","Williams J","Charlton K","Nolan JP","Rodrigues M","Snooks H","Brooker C","Starr KR","Wright A","Bywater D","Rai J","Perkins G","Waddington M","Strickland N","Chowdhury FJ","Pooles M","Goodacre S","Rowan K","Whitley GA","Long JB","MacKenzie R","Perkins GD","Rosser A","Deakin CD","Boldy R","Slowther AM","Sprauve L","Howkins G","Hutchinson D","Hepburn S","Miller J","Mason J","Nwankwo H","Starr K","Daffern C","Pringle L","Claxton Dip A","Lockley P","Deakin C","Kandiyali R","Jenkins S","Sears C","Limmer M","Quinn T","Skilton E","Black J","Regan S","Duncan E","Law S","Wood J","Prothero L","Holloway D","Fothergill R","Bradley G","Soar J","Irving S","Green Z","Black S","Eaton-Williams P","Wiltshire S","Mortimer C","Rees N","Noordali H","Lang N","Wiles JV","Chauhan M","Clarke R","Mills C","Coppola A","Brown C","Wyllie J","Mellett-Smith A","Spaight RES","Tibbetts B","Evans-Waugh C","McSheaffrey S","Foster T","Trebilcock H","Osborne R","Michelet F","Khalifa E","Evans C","Nokes T","Dra'gon V","Claxton A","Davidson B","Pocock H","Falloon J","Davidson N","Chowdhury L","Long E","Thom-Wood B","Long J","Mason JM","Norman C","Burrow E","Keeble B","Igbodo S","PARAMEDIC-3 Collaborators","Walker A","Smyth L","Squires GL","Millard R","Ji C","Phillips J","Jackson M","Kearney J","Devrell A","Smyth M","Smith H","Stanley O","Campbell M","Nolan J","Worsfold D","Gunson I","Smyth MA","Brown M","Thompson M","Bell S","Palti G","Oliver J","Couper K","Brown S","Lall R","Yu LM","Fothergill RT","Pennington B"],"additional_accession":[]},"is_claimable":false,"name":"A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest.","description":"Background
In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug administration than an intravenous route; however, its effect on clinical outcomes is uncertain.Methods
We conducted a multicenter, open-label, randomized trial across 11 emergency medical systems in the United Kingdom that involved adults in cardiac arrest for whom vascular access for drug administration was needed. Patients were randomly assigned to receive treatment from paramedics by means of an intraosseous-first or intravenous-first vascular access strategy. The primary outcome was survival at 30 days. Key secondary outcomes included any return of spontaneous circula","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T02:26:50.288Z","creation":"2025-04-04T02:26:50.288Z"},"accession":"S-EPMC7616768","cross_references":{"pubmed":["39480216"],"doi":["10.1056/NEJMoa2407780"]}}