biostudies-literatureTreur JLEuropean Research CouncilH2020 European Institute of Innovation and TechnologyFondation LeducqNIMH NIH HHSCanada Research Chairs153-161https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616879biostudies-literatureUnknown226(3)<h4>Background</h4>An important contributor to the decreased life expectancy of individuals with schizophrenia is sudden cardiac death. Arrhythmic disorders may play an important role herein, but the nature of the relationship between schizophrenia and arrhythmia is unclear.<h4>Aims</h4>To assess shared genetic liability and potential causal effects between schizophrenia and arrhythmic disorders and electrocardiogram (ECG) traits.<h4>Method</h4>We leveraged summary-level data of large-scale genome-wide association studies of schizophrenia (53 386 cases, 77 258 controls), arrhythmic disorders (atrial fibrillation, 55 114 cases, 482 295 controls; Brugada syndrome, 2820 cases, 10 001 controls) and ECG traits (heart rate (variability), PR interval, QT interval, JT interval and QRS duration, <iThe British journal of psychiatry : the journal of mental scienceAssociations of schizophrenia with arrhythmic disorders and electrocardiogram traits: genetic exploration of population samples.PMC7616879Starting Grant (UNRAVEL-CAUSALITY, grant number 10R01 MH123724101076686project 17CVD02CoMorMent project; Grant #84777Verweij KJHDenys DVermeulen JMPasman JABarc JSmit DJABezzina CRTreur JLThijssen ABBergstedt JVeeneman RRTadros RfalseAssociations of schizophrenia with arrhythmic disorders and electrocardiogram traits: genetic exploration of population samples.<h4>Background</h4>An important contributor to the decreased life expectancy of individuals with schizophrenia is sudden cardiac death. Arrhythmic disorders may play an important role herein, but the nature of the relationship between schizophrenia and arrhythmia is unclear.<h4>Aims</h4>To assess shared genetic liability and potential causal effects between schizophrenia and arrhythmic disorders and electrocardiogram (ECG) traits.<h4>Method</h4>We leveraged summary-level data of large-scale genome-wide association studies of schizophrenia (53 386 cases, 77 258 controls), arrhythmic disorders (atrial fibrillation, 55 114 cases, 482 295 controls; Brugada syndrome, 2820 cases, 10 001 controls) and ECG traits (heart rate (variability), PR interval, QT interval, JT interval and QRS duration, <i2025-01-01T00:00:00Z2025 Mar2026-06-03T00:54:41.439Z2025-04-06T15:09:54.214ZS-EPMC76168793951211410.1192/bjp.2024.165