biostudies-literatureCreamer AEPSRC Centre for Doctoral Training in NeurotechnologyCancer Research UKLifeArcKreftforeningenWolfson FoundationRoyal Academy of Engineering Chair in Emerging TechnologiesEPSRCUniversity College LondonEuropean CommissionInstitute of Cancer ResearchEngineering and Physical Sciences Research CouncilEPSRC IRC Agile Early Warning Sensing Systems for Infectious Diseases and Antimicrobial ResistanceNorges ForskningsrådetNFRAffibodyABH2020 Excellent ScienceECLeverhulme TrustRosetreesUK Regenerative Medicine PlatformRoyal SocietyRosetrees TrustAker ScholarshipMedical Research CouncilWellcome TrustEPRSC and SFI Centre for Doctoral Training in Advanced Characterisation of Materialse2300413https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616993biostudies-literatureUnknown36(20)Semiconducting polymer nanoparticles (SPNs) are explored for applications in cancer theranostics because of their high absorption coefficients, photostability, and biocompatibility. However, SPNs are susceptible to aggregation and protein fouling in physiological conditions, which can be detrimental for in vivo applications. Here, a method for achieving colloidally stable and low-fouling SPNs is described by grafting poly(ethylene glycol) (PEG) onto the backbone of the fluorescent semiconducting polymer, poly(9,9'-dioctylfluorene-5-fluoro-2,1,3-benzothiadiazole), in a simple one-step substitution reaction, postpolymerization. Further, by utilizing azide-functionalized PEG, anti-human epidermal growth factor receptor 2 (HER2) antibodies, antibody fragments, or affibodies are site-specificalAdvanced materials (Deerfield Beach, Fla.)Modular Synthesis of Semiconducting Graft Copolymers to Achieve "Clickable" Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting.PMC7616993EP/S023259/1EP/K031953/1100063209121EP/L016737/1EP/K020641/12788631468429385M300-F2EDDPMA-May21\100063EP/R00529X/1209121_Z_17_ZEP/T517793/1CiET2021/94209121/Z/17/ZEP/S023518/1MR/R015651/1M945859458EP/J021199/1711091PhD2022 100021PhD2021 1000222758732733191975550de la Ballina LRHogset HShamsabadi ARochet LNCCreamer APrados-Martin LKim NTang JBugeon LThanasi IAChudasama VKramer-Marek GDallman MJLove EAFoote JEJFenaroli FRapley CLHeeney MTurnock SStevens MMRichards DAAgliano AMonahan ANajer AWojciechowski JPFiego ALfalseModular Synthesis of Semiconducting Graft Copolymers to Achieve "Clickable" Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting.Semiconducting polymer nanoparticles (SPNs) are explored for applications in cancer theranostics because of their high absorption coefficients, photostability, and biocompatibility. However, SPNs are susceptible to aggregation and protein fouling in physiological conditions, which can be detrimental for in vivo applications. Here, a method for achieving colloidally stable and low-fouling SPNs is described by grafting poly(ethylene glycol) (PEG) onto the backbone of the fluorescent semiconducting polymer, poly(9,9'-dioctylfluorene-5-fluoro-2,1,3-benzothiadiazole), in a simple one-step substitution reaction, postpolymerization. Further, by utilizing azide-functionalized PEG, anti-human epidermal growth factor receptor 2 (HER2) antibodies, antibody fragments, or affibodies are site-specifical2024-01-01T00:00:00Z2024 May2025-04-03T23:18:21.638Z2025-04-03T23:18:21.638ZS-EPMC76169933690568310.1002/adma.202300413