biostudies-literatureNguyen Ho PTNIA NIH HHSZonMw5506-5517https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616996biostudies-literatureUnknown19(12)<h4>Introduction</h4>Reliable models to predict amyloid beta (Aβ) positivity in the general aging population are lacking but could become cost-efficient tools to identify individuals at risk of developing Alzheimer's disease.<h4>Methods</h4>We developed Aβ prediction models in the clinical Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study (n = 4,119) including a broad range of easily ascertainable predictors (demographics, cognition and daily functioning, health and lifestyle factors). Importantly, we determined the generalizability of our models in the population-based Rotterdam Study (n = 500).<h4>Results</h4>The best performing model in the A4 Study (area under the curve [AUC] = 0.73 [0.69-0.76]), including age, apolipoprotein E (APOE) ε4 genotype, family history of dementiaAlzheimer's & dementia : the journal of the Alzheimer's AssociationPredicting amyloid-beta pathology in the general population.PMC7616996#10510032120003#7330509500710510032120003P01 AG03669473305095007733050817Vernooij MWNguyen Ho PTvan Rooij FJARoshchupkin GVIkram MAvan Arendonk JNeitzel JSteketee RMEfalsePredicting amyloid-beta pathology in the general population.<h4>Introduction</h4>Reliable models to predict amyloid beta (Aβ) positivity in the general aging population are lacking but could become cost-efficient tools to identify individuals at risk of developing Alzheimer's disease.<h4>Methods</h4>We developed Aβ prediction models in the clinical Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study (n = 4,119) including a broad range of easily ascertainable predictors (demographics, cognition and daily functioning, health and lifestyle factors). Importantly, we determined the generalizability of our models in the population-based Rotterdam Study (n = 500).<h4>Results</h4>The best performing model in the A4 Study (area under the curve [AUC] = 0.73 [0.69-0.76]), including age, apolipoprotein E (APOE) ε4 genotype, family history of dementia2023-01-01T00:00:00Z2023 Dec2026-06-01T17:45:43.325Z2025-04-04T12:25:33.413ZS-EPMC76169963730311610.1002/alz.13161