{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lavrador P"],"funding":["Fundação para a Ciência e a Tecnologia","European Research Council"],"pagination":["e1800890"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(19)"],"pubmed_abstract":["Naringin is a naturally occurring flavanone with recognized neuroprotective, cardioprotective, anti-inflammatory, and antiosteoporotic properties. Herein, the delivery of Naringin-loaded methoxy-poly(ethylene glycol)-maleimide-thiol-poly(l-lactide) (mPEGMSPLA) diblock polymeric micelles to human adipose-derived stem cells (hASCs) with the aim to augment its pro-osteogenic effect in these cells is reported for the first time. The synthesis of the diblock copolymer is performed via Michael-type addition reaction between hydrophilic methoxy-poly(ethylene glycol)-maleimide (mPEGMAL) and hydrophobic thiol-poly(l-lactide) (PLASH) and confirmed by 1 H NMR and attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectroscopy. The resulting mPEGMSPLA copolymer self-"],"journal":["Advanced healthcare materials"],"pubmed_title":["Bioinstructive Naringin-Loaded Micelles for Guiding Stem Cell Osteodifferentiation."],"pmcid":["PMC7617004"],"funding_grant_id":["ERC-2014-ADG-669858","UID /CTM /50011/2013","669858","ERC‐2014‐ADG‐669858"],"pubmed_authors":["Mano JF","Gaspar VM","Lavrador P"],"additional_accession":[]},"is_claimable":false,"name":"Bioinstructive Naringin-Loaded Micelles for Guiding Stem Cell Osteodifferentiation.","description":"Naringin is a naturally occurring flavanone with recognized neuroprotective, cardioprotective, anti-inflammatory, and antiosteoporotic properties. Herein, the delivery of Naringin-loaded methoxy-poly(ethylene glycol)-maleimide-thiol-poly(l-lactide) (mPEGMSPLA) diblock polymeric micelles to human adipose-derived stem cells (hASCs) with the aim to augment its pro-osteogenic effect in these cells is reported for the first time. The synthesis of the diblock copolymer is performed via Michael-type addition reaction between hydrophilic methoxy-poly(ethylene glycol)-maleimide (mPEGMAL) and hydrophobic thiol-poly(l-lactide) (PLASH) and confirmed by 1 H NMR and attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectroscopy. The resulting mPEGMSPLA copolymer self-","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2025-04-21T21:52:39.682Z","creation":"2025-04-21T21:52:39.682Z"},"accession":"S-EPMC7617004","cross_references":{"pubmed":["30106519"],"doi":["10.1002/adhm.201800890"]}}