biostudies-literatureLavrador PFundação para a Ciência e a TecnologiaEuropean Research Councile1800890https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617004biostudies-literatureUnknown7(19)Naringin is a naturally occurring flavanone with recognized neuroprotective, cardioprotective, anti-inflammatory, and antiosteoporotic properties. Herein, the delivery of Naringin-loaded methoxy-poly(ethylene glycol)-maleimide-thiol-poly(l-lactide) (mPEGMSPLA) diblock polymeric micelles to human adipose-derived stem cells (hASCs) with the aim to augment its pro-osteogenic effect in these cells is reported for the first time. The synthesis of the diblock copolymer is performed via Michael-type addition reaction between hydrophilic methoxy-poly(ethylene glycol)-maleimide (mPEGMAL) and hydrophobic thiol-poly(l-lactide) (PLASH) and confirmed by <sup>1</sup> H NMR and attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectroscopy. The resulting mPEGMSPLA copolymer self-Advanced healthcare materialsBioinstructive Naringin-Loaded Micelles for Guiding Stem Cell Osteodifferentiation.PMC7617004ERC-2014-ADG-669858UID /CTM /50011/2013669858ERC‐2014‐ADG‐669858Mano JFGaspar VMLavrador PfalseBioinstructive Naringin-Loaded Micelles for Guiding Stem Cell Osteodifferentiation.Naringin is a naturally occurring flavanone with recognized neuroprotective, cardioprotective, anti-inflammatory, and antiosteoporotic properties. Herein, the delivery of Naringin-loaded methoxy-poly(ethylene glycol)-maleimide-thiol-poly(l-lactide) (mPEGMSPLA) diblock polymeric micelles to human adipose-derived stem cells (hASCs) with the aim to augment its pro-osteogenic effect in these cells is reported for the first time. The synthesis of the diblock copolymer is performed via Michael-type addition reaction between hydrophilic methoxy-poly(ethylene glycol)-maleimide (mPEGMAL) and hydrophobic thiol-poly(l-lactide) (PLASH) and confirmed by <sup>1</sup> H NMR and attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectroscopy. The resulting mPEGMSPLA copolymer self-2018-01-01T00:00:00Z2018 Oct2025-04-21T21:52:39.682Z2025-04-21T21:52:39.682ZS-EPMC76170043010651910.1002/adhm.201800890