{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clarke SLN"],"funding":["University of Bristol","Medical Research Council","Wellcome Trust"],"pagination":["674-681"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617134"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(3)"],"pubmed_abstract":["Objectives
Observational studies report mixed findings regarding the association between vitamin D and juvenile idiopathic arthritis (JIA) incidence or activity; however, such studies are susceptible to considerable bias. Because low vitamin D levels are common within the general population and easily corrected, there is potential public health benefit in identifying a causal association between vitamin D insufficiency and JIA incidence. To limit bias due to confounding and reverse causation, we examined the causal effect of the major circulating form of vitamin D, 25-hydroxy vitamin D (25-[OH]D), on JIA incidence using Mendelian randomization (MR).Methods
In this 2-sample MR analysis, we used summary level data from the largest and most recent genome-wide association study"],"journal":["Arthritis care & research"],"pubmed_title":["Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study."],"pmcid":["PMC7617134"],"funding_grant_id":["211030","203918","MR/R013926/1","MC‐UU‐00011‐5","203918/Z/16/Z","MR/S009310/1","MC_UU_00032/4","MC_UU_00011/5","211030/Z/18/Z"],"pubmed_authors":["Ramanan AV","Sharp GC","Relton CL","Clarke SLN","Mitchell RE"],"additional_accession":[]},"is_claimable":false,"name":"Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study.","description":"Objectives
Observational studies report mixed findings regarding the association between vitamin D and juvenile idiopathic arthritis (JIA) incidence or activity; however, such studies are susceptible to considerable bias. Because low vitamin D levels are common within the general population and easily corrected, there is potential public health benefit in identifying a causal association between vitamin D insufficiency and JIA incidence. To limit bias due to confounding and reverse causation, we examined the causal effect of the major circulating form of vitamin D, 25-hydroxy vitamin D (25-[OH]D), on JIA incidence using Mendelian randomization (MR).Methods
In this 2-sample MR analysis, we used summary level data from the largest and most recent genome-wide association study","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-03T23:56:02.659Z","creation":"2025-04-03T23:56:02.659Z"},"accession":"S-EPMC7617134","cross_references":{"pubmed":["34748291"],"doi":["10.1002/acr.24815"]}}