{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Faas M"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","European Research Council","Friedrich-Alexander-Universität Erlangen-Nürnberg"],"pagination":["2531-2546.e5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617137"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(11)"],"pubmed_abstract":["Alternatively activated macrophages (AAMs) contribute to the resolution of inflammation and tissue repair. However, molecular pathways that govern their differentiation have remained incompletely understood. Here, we show that uncoupling protein-2-mediated mitochondrial reprogramming and the transcription factor GATA3 specifically controlled the differentiation of pro-resolving AAMs in response to the alarmin IL-33. In macrophages, IL-33 sequentially triggered early expression of pro-inflammatory genes and subsequent differentiation into AAMs. Global analysis of underlying signaling events revealed that IL-33 induced a rapid metabolic rewiring of macrophages that involved uncoupling of the respiratory chain and increased production of the metabolite itaconate, which subsequently triggered "],"journal":["Immunity"],"pubmed_title":["IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation."],"pmcid":["PMC7617137"],"funding_grant_id":["261193037","GK1660","B01/A03","640087","FG 2886","CRC1181-A03/A01/A02/Z2","810316","101001866"],"pubmed_authors":["Schroder F","Gruneboom A","Kirchner P","Culemann S","Faas M","Mougiakakos D","Kronke G","Rothe T","Ipseiz N","Stoll C","Schett G","Wirtz S","Voehringer D","Bottcher M","Kunz M","Eberhardt M","Uderhardt S","Vera J","Michelucci A","Ackermann J","Ekici A","Fuchs M","Hofmann J","Lang R","Scholtysek C","Weigmann B"],"additional_accession":[]},"is_claimable":false,"name":"IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.","description":"Alternatively activated macrophages (AAMs) contribute to the resolution of inflammation and tissue repair. However, molecular pathways that govern their differentiation have remained incompletely understood. Here, we show that uncoupling protein-2-mediated mitochondrial reprogramming and the transcription factor GATA3 specifically controlled the differentiation of pro-resolving AAMs in response to the alarmin IL-33. In macrophages, IL-33 sequentially triggered early expression of pro-inflammatory genes and subsequent differentiation into AAMs. Global analysis of underlying signaling events revealed that IL-33 induced a rapid metabolic rewiring of macrophages that involved uncoupling of the respiratory chain and increased production of the metabolite itaconate, which subsequently triggered ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-06-03T01:09:23.209Z","creation":"2025-04-03T23:18:48.067Z"},"accession":"S-EPMC7617137","cross_references":{"pubmed":["34644537"],"doi":["10.1016/j.immuni.2021.09.010"]}}