{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Parker CC"],"funding":["Cancer Research Campaign","Cancer Research UK","Canadian Cancer Society","UKRI Medical Research Council","Medical Research Council"],"pagination":["656-666"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617161"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(7)"],"pubmed_abstract":["<h4>Background</h4>The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for prostate-specific antigen (PSA) failure.<h4>Patients and methods</h4>RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, preoperative PSA≥10 ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ('Adjuvant-RT') or an observation policy with salvage RT for PSA failure ('Salvage-RT') defined as PSA≥0.1 ng/ml or three consecutive rises. Stratification factors were Gleason score, margin status, planned RT schedule (52.5 Gy/20 fractions or 66 Gy/33 fracti"],"journal":["Annals of oncology : official journal of the European Society for Medical Oncology"],"pubmed_title":["Timing of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047)."],"pmcid":["PMC7617161"],"funding_grant_id":["MC_UU_12023/28","MC_UU_00004/02","6381"],"pubmed_authors":["Kynaston H","Sundaram S","Wells P","Wilson J","Bahl AK","Parmar MKB","Brasso K","Morris SL","Simms M","Patel P","Owen L","Lees K","Makar A","Pope A","Cook AD","Jaganathan R","James ND","Clarke NW","Lester J","Tarver KL","Zarkar AM","Cross WR","Ramani V","Cooke PW","Oommen N","Henderson A","Lindberg H","Bower L","Noor D","Henry A","Jakobsen H","Sydes MR","Donohue JF","Saad F","Capaldi L","RADICALS investigators","Eddy B","Sayers I","Srinivasan V","Popert R","Maniatis C","Petersen PM","Ostler P","Tran A","Roder A","Bottomley DM","Raman R","Parulekar WR","Heath CM","Anderson J","Bashir F","Chung C","Payne H","Joseph J","Catton C","Persad RA","Durkan GC","Logue J","Parker CC"],"additional_accession":[]},"is_claimable":false,"name":"Timing of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047).","description":"<h4>Background</h4>The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for prostate-specific antigen (PSA) failure.<h4>Patients and methods</h4>RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, preoperative PSA≥10 ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ('Adjuvant-RT') or an observation policy with salvage RT for PSA failure ('Salvage-RT') defined as PSA≥0.1 ng/ml or three consecutive rises. Stratification factors were Gleason score, margin status, planned RT schedule (52.5 Gy/20 fractions or 66 Gy/33 fracti","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-22T03:14:41.992Z","creation":"2025-04-06T22:21:03.794Z"},"accession":"S-EPMC7617161","cross_references":{"pubmed":["38583574"],"doi":["10.1016/j.annonc.2024.03.010"]}}