biostudies-literatureParker CCCancer Research CampaignCancer Research UKCanadian Cancer SocietyUKRI Medical Research CouncilMedical Research Council656-666https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617161biostudies-literatureUnknown35(7)<h4>Background</h4>The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for prostate-specific antigen (PSA) failure.<h4>Patients and methods</h4>RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, preoperative PSA≥10 ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ('Adjuvant-RT') or an observation policy with salvage RT for PSA failure ('Salvage-RT') defined as PSA≥0.1 ng/ml or three consecutive rises. Stratification factors were Gleason score, margin status, planned RT schedule (52.5 Gy/20 fractions or 66 Gy/33 fractiAnnals of oncology : official journal of the European Society for Medical OncologyTiming of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047).PMC7617161MC_UU_12023/28MC_UU_00004/026381Kynaston HSundaram SWells PWilson JBahl AKParmar MKBBrasso KMorris SLSimms MPatel POwen LLees KMakar APope ACook ADJaganathan RJames NDClarke NWLester JTarver KLZarkar AMCross WRRamani VCooke PWOommen NHenderson ALindberg HBower LNoor DHenry AJakobsen HSydes MRDonohue JFSaad FCapaldi LRADICALS investigatorsEddy BSayers ISrinivasan VPopert RManiatis CPetersen PMOstler PTran ARoder ABottomley DMRaman RParulekar WRHeath CMAnderson JBashir FChung CPayne HJoseph JCatton CPersad RADurkan GCLogue JParker CCfalseTiming of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047).<h4>Background</h4>The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for prostate-specific antigen (PSA) failure.<h4>Patients and methods</h4>RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, preoperative PSA≥10 ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ('Adjuvant-RT') or an observation policy with salvage RT for PSA failure ('Salvage-RT') defined as PSA≥0.1 ng/ml or three consecutive rises. Stratification factors were Gleason score, margin status, planned RT schedule (52.5 Gy/20 fractions or 66 Gy/33 fracti2024-01-01T00:00:00Z2024 Jul2026-04-22T03:14:41.992Z2025-04-06T22:21:03.794ZS-EPMC76171613858357410.1016/j.annonc.2024.03.010