biostudies-literatureBodien YGNCATS NIH HHSNICHD NIH HHSNational Institute for Health Research (NIHR)NINDS NIH HHSJames S. McDonnell Foundation598-608https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617195biostudies-literatureUnknown391(7)<h4>Background</h4>Patients with brain injury who are unresponsive to commands may perform cognitive tasks that are detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phenomenon, known as cognitive motor dissociation, has not been systematically studied in a large cohort of persons with disorders of consciousness.<h4>Methods</h4>In this prospective cohort study conducted at six international centers, we collected clinical, behavioral, and task-based fMRI and EEG data from a convenience sample of 353 adults with disorders of consciousness. We assessed the response to commands on task-based fMRI or EEG in participants without an observable response to verbal commands (i.e., those with a behavioral diagnosis of coma, vegetative state, or minimally The New England journal of medicineCognitive Motor Dissociation in Disorders of Consciousness.PMC7617195UL1 TR002384NIHR203312UL1 TR001866NF-SI-0512-10090DP2 HD101400R01 HD051912R01 NS106014R03 NS112760Schiff NDValente MSitt JDCardone PChatelle CBodien YGVelazquez AFins JJGiacino JTVrosgou AVoss HUDehaene SBagiella ECarmona JLupson VCMenon DStamatakis EASoddu AOwen AMHersh JEMeydan AHeinonen GEdlow BLNaccache LLaureys SRohaut BGosseries OConte MFinoia PThibaut AAllanson JPickard JKamau EVictor JDChennu SLawrence PKSanders WRClaassen JBonhomme AfalseCognitive Motor Dissociation in Disorders of Consciousness.<h4>Background</h4>Patients with brain injury who are unresponsive to commands may perform cognitive tasks that are detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phenomenon, known as cognitive motor dissociation, has not been systematically studied in a large cohort of persons with disorders of consciousness.<h4>Methods</h4>In this prospective cohort study conducted at six international centers, we collected clinical, behavioral, and task-based fMRI and EEG data from a convenience sample of 353 adults with disorders of consciousness. We assessed the response to commands on task-based fMRI or EEG in participants without an observable response to verbal commands (i.e., those with a behavioral diagnosis of coma, vegetative state, or minimally 2024-01-01T00:00:00Z2024 Aug2025-04-22T16:56:39.5Z2025-04-06T01:54:38.326ZS-EPMC76171953914185210.1056/NEJMoa2400645