{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(12)"],"submitter":["Ferreira LP"],"funding":["Fundação para a Ciência e a Tecnologia","European Research Council"],"pubmed_abstract":["In vitro 3D tumor microenvironment mimicking models are gathering momentum as alternatives to traditional 2D flat monolayer cultures due to their potential for recapitulating major cancer hallmarks. To fulfill such potential, it is crucial that 3D tumor testing platforms completely emulate in vitro the complex in vivo tumor niche and its cellular constituents. Mesenchymal stem cells (MSCs) are recognized to play a pivotal multi-modulatory role in cancer, generating interest as biological targets and as key tumor suppressing, or tumor promoting effectors. This review discusses the biological influence of different types of MSCs in the tumor microenvironment and showcases recent studies that engineer 3D MSCs-cancer cells co-cultures as advanced in vitro therapy testing platforms. A special f"],"journal":["Biotechnology journal"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617208"],"repository":["biostudies-literature"],"pubmed_title":["Mesenchymal Stem Cells Relevance in Multicellular Bioengineered 3D In Vitro Tumor Models."],"pmcid":["PMC7617208"],"funding_grant_id":["SFRH/BPD/119983/2016","669858","ERC‐2014‐ADG‐669858"],"pubmed_authors":["Henrique R","Mano JF","Ferreira LP","Gaspar VM","Jeronimo C"],"additional_accession":[]},"is_claimable":false,"name":"Mesenchymal Stem Cells Relevance in Multicellular Bioengineered 3D In Vitro Tumor Models.","description":"In vitro 3D tumor microenvironment mimicking models are gathering momentum as alternatives to traditional 2D flat monolayer cultures due to their potential for recapitulating major cancer hallmarks. To fulfill such potential, it is crucial that 3D tumor testing platforms completely emulate in vitro the complex in vivo tumor niche and its cellular constituents. Mesenchymal stem cells (MSCs) are recognized to play a pivotal multi-modulatory role in cancer, generating interest as biological targets and as key tumor suppressing, or tumor promoting effectors. This review discusses the biological influence of different types of MSCs in the tumor microenvironment and showcases recent studies that engineer 3D MSCs-cancer cells co-cultures as advanced in vitro therapy testing platforms. A special f","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2025-04-18T14:39:58.657Z","creation":"2025-04-07T00:56:27.502Z"},"accession":"S-EPMC7617208","cross_references":{"pubmed":["28834355"],"doi":["10.1002/biot.201700079"]}}