{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iyer DP"],"funding":["Alexander von Humboldt Foundation","Austrian Science Fund FWF","Cancer Research UK","Swiss National Science Foundation","Francis Crick Institute","European Research Council","Medical Research Council","Horizon 2020","Max Planck Society","Wellcome Trust","Vienna BioCenter","DAAD"],"pagination":["6566-6583.e22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617234"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["187(23)"],"pubmed_abstract":["Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway. It is unknown whether this ability is conserved in mammals in general and in humans in particular. Here, we show that decreasing the activity of the mTOR signaling pathway induces human pluripotent stem cells (hPSCs) and blastoids to enter a dormant state with limited proliferation, developmental progression, and capacity to attach to endometrial cells. These in vitro assays show that, similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage and is reversible at both functional and molecular levels. "],"journal":["Cell"],"pubmed_title":["mTOR activity paces human blastocyst stage developmental progression."],"pmcid":["PMC7617234"],"funding_grant_id":["360G-Wellcome-215116_Z_18_Z","91730547","P2EZP3_195682","101026451","FC001120","101002317","M 3131","M3131-B"],"pubmed_authors":["Khoei HH","Kagawa H","Simon CS","Rivron N","Snell P","Pradhan SJ","Schulz EG","Iyer DP","Christie L","Dunkel I","Novatchkova M","Wamaitha SE","Bulut-Karslioglu A","McCarthy A","van der Weijden VA","Rayon T","Elder K","Niakan KK"],"additional_accession":[]},"is_claimable":false,"name":"mTOR activity paces human blastocyst stage developmental progression.","description":"Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway. It is unknown whether this ability is conserved in mammals in general and in humans in particular. Here, we show that decreasing the activity of the mTOR signaling pathway induces human pluripotent stem cells (hPSCs) and blastoids to enter a dormant state with limited proliferation, developmental progression, and capacity to attach to endometrial cells. These in vitro assays show that, similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage and is reversible at both functional and molecular levels. ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-15T21:54:18.644Z","creation":"2025-04-03T23:18:59.893Z"},"accession":"S-EPMC7617234","cross_references":{"pubmed":["39332412"],"doi":["10.1016/j.cell.2024.08.048"]}}