{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Parker CC"],"funding":["NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","Cancer Research UK","Canadian Cancer Society","UKRI Medical Research Council","Medical Research Council","University College London"],"pagination":["422-430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86(5)"],"pubmed_abstract":["<h4>Background and objective</h4>The use and duration of androgen deprivation therapy (ADT) with postoperative radiotherapy (RT) have been uncertain. RADICALS-HD compared adding no (\"None\"), 6-months (\"Short\"), or 24-mo (\"Long\") ADT to study efficacy in the long term.<h4>Methods</h4>Participants with prostate cancer were indicated for postoperative RT and agreed randomisation between all durations. ADT was allocated for 0, 6, or 24 mo. The primary outcome measure (OM) was metastasis-free survival (MFS). The secondary OMs included freedom from distant metastasis, overall survival, and initiation of nonprotocol ADT. Sample size was determined by two-way comparisons. Analyses followed standard time-to-event approaches and intention-to-treat principles.<h4>Key findings and limitations</h4>Betw"],"journal":["European urology"],"pubmed_title":["Randomised Trial of No, Short-term, or Long-term Androgen Deprivation Therapy with Postoperative Radiotherapy After Radical Prostatectomy: Results from the Three-way Comparison of RADICALS-HD (NCT00541047)."],"pmcid":["PMC7617288"],"funding_grant_id":["UK/C7829/A6381","MC_UU_12023/28","6381","MC_UU_00004/02"],"pubmed_authors":["Catton CN","Petersen PM","Bower L","Cook AD","Sydes MR","Kynaston H","Clarke NW","Parmar MKB","Amos C","Raman R","Parulekar WR","RADICALS Investigators","Saad F","Payne H","Worlding J","Cross WR","Persad RA","Sayers I","Logue J","Parker CC"],"additional_accession":[]},"is_claimable":false,"name":"Randomised Trial of No, Short-term, or Long-term Androgen Deprivation Therapy with Postoperative Radiotherapy After Radical Prostatectomy: Results from the Three-way Comparison of RADICALS-HD (NCT00541047).","description":"<h4>Background and objective</h4>The use and duration of androgen deprivation therapy (ADT) with postoperative radiotherapy (RT) have been uncertain. RADICALS-HD compared adding no (\"None\"), 6-months (\"Short\"), or 24-mo (\"Long\") ADT to study efficacy in the long term.<h4>Methods</h4>Participants with prostate cancer were indicated for postoperative RT and agreed randomisation between all durations. ADT was allocated for 0, 6, or 24 mo. The primary outcome measure (OM) was metastasis-free survival (MFS). The secondary OMs included freedom from distant metastasis, overall survival, and initiation of nonprotocol ADT. Sample size was determined by two-way comparisons. Analyses followed standard time-to-event approaches and intention-to-treat principles.<h4>Key findings and limitations</h4>Betw","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-04-18T03:24:21.965Z","creation":"2026-04-18T03:11:44.313Z"},"accession":"S-EPMC7617288","cross_references":{"pubmed":["39217077"],"doi":["10.1016/j.eururo.2024.07.026"]}}