biostudies-literatureKahan BCMedical Research Council2106-2114https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617336biostudies-literatureUnknown330(21)<h4>Importance</h4>Transparent reporting of randomized trials is essential to facilitate critical appraisal and interpretation of results. Factorial trials, in which 2 or more interventions are assessed in the same set of participants, have unique methodological considerations. However, reporting of factorial trials is suboptimal.<h4>Objective</h4>To develop a consensus-based extension to the Consolidated Standards of Reporting Trials (CONSORT) 2010 Statement for factorial trials.<h4>Design</h4>Using the Enhancing the Quality and Transparency of Health Research (EQUATOR) methodological framework, the CONSORT extension for factorial trials was developed by (1) generating a list of reporting recommendations for factorial trials using a scoping review of methodological articles identified usiJAMAReporting of Factorial Randomized Trials: Extension of the CONSORT 2010 Statement.PMC7617336MC_UU_00004/07MR/V020803/1MC_UU_00004/09Goulao BHopewell SBirchenall MChan AWFletcher JLittle PHall SSJuszczak EBeller EMKahan BCMontgomery AAGolub RMElbourne DIslam NZwarenstein MfalseReporting of Factorial Randomized Trials: Extension of the CONSORT 2010 Statement.<h4>Importance</h4>Transparent reporting of randomized trials is essential to facilitate critical appraisal and interpretation of results. Factorial trials, in which 2 or more interventions are assessed in the same set of participants, have unique methodological considerations. However, reporting of factorial trials is suboptimal.<h4>Objective</h4>To develop a consensus-based extension to the Consolidated Standards of Reporting Trials (CONSORT) 2010 Statement for factorial trials.<h4>Design</h4>Using the Enhancing the Quality and Transparency of Health Research (EQUATOR) methodological framework, the CONSORT extension for factorial trials was developed by (1) generating a list of reporting recommendations for factorial trials using a scoping review of methodological articles identified usi2023-01-01T00:00:00Z2023 Dec2025-04-04T01:35:48.351Z2025-04-04T01:35:48.351ZS-EPMC76173363805132410.1001/jama.2023.19793