biostudies-literatureNebgen DRMedical Research CouncilNational Institute for Health Research (NIHR)1437-1450https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617419biostudies-literatureUnknown130(12)Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.BJOG : an international journal of obstetrics and gynaecologyCare after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations.PMC7617419IS-BRC-1215-20007NIHR300650MC_UU_00004/01Crosbie EJBrood-van Zanten MMAMarchetti CNebgen DRMenon UKingsberg SAda Silva Filho ALEvans DGGrandi GKurian AWParamanandam VSGuise TGuidozzi FDomchek SMNorquist BMYuksel NKotsopoulos JRozenberg SBober SLJohansen NHickey MBrennan DJde Hullu JAJacobson MPowell CBPederson HJMichaelson-Cohen RfalseCare after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations.Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.2023-01-01T00:00:00Z2023 Nov2025-04-18T12:58:33.9Z2025-04-06T22:26:05.077ZS-EPMC76174193713212610.1111/1471-0528.17511