biostudies-literatureAfzali MBritish Heart FoundationEPSRCWellcome TrustBritish Heart Foundation, UKEngineering and Physical Sciences Research Council1022-1034https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617480biostudies-literatureUnknown92(3)<h4>Purpose</h4>This work reports for the first time on the implementation and application of cardiac diffusion-weighted MRI on a Connectom MR scanner with a maximum gradient strength of 300 mT/m. It evaluates the benefits of the increased gradient performance for the investigation of the myocardial microstructure.<h4>Methods</h4>Cardiac diffusion-weighted imaging (DWI) experiments were performed on 10 healthy volunteers using a spin-echo sequence with up to second- and third-order motion compensation ( M2$$ {M}_2 $$ and M3$$ {M}_3 $$ ) and b=100, 450$$ b=100,450 $$ , and 1000 s/mm2$$ \mathrm{s}/\mathrm{m}{\mathrm{m}}^2 $$ (twice the bmax$$ {b}_{\mathrm{max}} $$ commonly used on clinical scanners). Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and secondary eigenvectMagnetic resonance in medicineIn vivo diffusion MRI of the human heart using a 300 mT/m gradient system.PMC7617480219536096646/Z/11/ZPG/19/1/34076EP/M029778/1104943/Z/14/Z104943219536/Z/19/Z096646Schneider JEJones DKSzczepankiewicz FAfzali MFasano FMueller LCoveney SEvans CJEngel MTeh IDall'Armellina EfalseIn vivo diffusion MRI of the human heart using a 300 mT/m gradient system.<h4>Purpose</h4>This work reports for the first time on the implementation and application of cardiac diffusion-weighted MRI on a Connectom MR scanner with a maximum gradient strength of 300 mT/m. It evaluates the benefits of the increased gradient performance for the investigation of the myocardial microstructure.<h4>Methods</h4>Cardiac diffusion-weighted imaging (DWI) experiments were performed on 10 healthy volunteers using a spin-echo sequence with up to second- and third-order motion compensation ( M2$$ {M}_2 $$ and M3$$ {M}_3 $$ ) and b=100, 450$$ b=100,450 $$ , and 1000 s/mm2$$ \mathrm{s}/\mathrm{m}{\mathrm{m}}^2 $$ (twice the bmax$$ {b}_{\mathrm{max}} $$ commonly used on clinical scanners). Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and secondary eigenvect2024-01-01T00:00:00Z2024 Sep2026-05-29T19:11:49.542Z2026-04-08T05:45:36.63ZS-EPMC76174803865039510.1002/mrm.30118