biostudies-literatureKumar SImpacting Research Innovation and TechnologyDepartment of Science and Technology, Ministry of Science and Technology, IndiaDBT/Wellcome Trust India AllianceHyderabad Eye Research FoundationDepartment of Biotechnology, Ministry of Science and Technology, India3171-3187https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617615biostudies-literatureUnknown168(9)Extremely preterm infants are at risk of developing retinopathy of prematurity (ROP), characterized by neovascularization and neuroinflammation leading to blindness. Polyunsaturated fatty acid (PUFA) supplementation is recommended in preterm infants to lower the risk of ROP, however, with no significant improvement in visual acuity. Reasonably, this could be as a result of the non-consideration of PUFA metabolizing enzymes. We hypothesize that abnormal metabolism of the arachidonic acid (AA) pathway may contribute to severe stages of ROP. The present study investigated the AA-metabolizing enzymes in ROP pathogenesis by a targeted gene expression analysis of blood (severe ROP = 70, No/Mild = 56), placenta (preterm placenta = 6, full term placenta = 3), and human primary retinal cell cultureJournal of neurochemistryArachidonic acid metabolism regulates the development of retinopathy of prematurity among preterm infants.PMC7617615IMP/2018/001414BT/PR32404/MED/30/2136/2019IF190699DBT/2020/LVPEI/1365IA/E/22/1/506766LEC02‐14‐029LEC02-14-029Sharma NMahajan AJalali SKaur IJoshi MBKekunnaya RChakrabarti SKaur TKumar SPatnaik SfalseArachidonic acid metabolism regulates the development of retinopathy of prematurity among preterm infants.Extremely preterm infants are at risk of developing retinopathy of prematurity (ROP), characterized by neovascularization and neuroinflammation leading to blindness. Polyunsaturated fatty acid (PUFA) supplementation is recommended in preterm infants to lower the risk of ROP, however, with no significant improvement in visual acuity. Reasonably, this could be as a result of the non-consideration of PUFA metabolizing enzymes. We hypothesize that abnormal metabolism of the arachidonic acid (AA) pathway may contribute to severe stages of ROP. The present study investigated the AA-metabolizing enzymes in ROP pathogenesis by a targeted gene expression analysis of blood (severe ROP = 70, No/Mild = 56), placenta (preterm placenta = 6, full term placenta = 3), and human primary retinal cell culture2024-01-01T00:00:00Z2024 Sep2026-06-02T17:34:19.36Z2025-07-12T03:04:36.445ZS-EPMC76176153907312010.1111/jnc.16190