{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu Y"],"funding":["Ministry of Science and Technology of the People's Republic of China","Cancer Research UK","British Heart Foundation","Noncommunicable Chronic Diseases-National Science and Technology Major Project","Kadoorie Charitable Foundation","Ministry of Science and Technology of the People&apos;s Republic of China","Medical Research Council","National Natural Science Foundation of China","Wellcome Trust","National Key Research and Development Program of China","Kadoorie Charitable Foundation in Hong Kong"],"pagination":["346-358"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617645"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(4)"],"pubmed_abstract":["<h4>Background and objective</h4>Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.<h4>Methods</h4>Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome-wide association (GWAS) summary statistics of snoring and BMI from CKB (n = 100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891-25,892 cases, 142,336-168,186 controls). Single-variable and multivariable two-sample bi-directional Mendelian randomization (MR) analyses were perfor"],"journal":["Respirology (Carlton, Vic.)"],"pubmed_title":["Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia."],"pmcid":["PMC7617645"],"funding_grant_id":["088158/Z/09/Z","2011BAI09B01","104085","C16077/A29186","CH/1996001/9454","202922/Z/16/Z","202922","MC_UU_12026/2","81941018","C500/A16896","212946","16896","MC_UU_00017/1","2016YFC0900500","MC_U137686851","A29186","104085/Z/14/Z","212946/Z/18/Z","91846303","2023ZD0510100","088158","81390540","82388102","82192900","82192901","82192904"],"pubmed_authors":["Peng Y","Fang K","Guo Z","Hu Y","Zhang J","Wright N","Zhang H","Zhang N","Shen D","Su J","Zhang L","Zhang S","Walters R","Ryder P","Jin D","Jin J","Yuan W","Jin L","Zheng X","Turnbull I","Yuan M","Lan Y","Xu J","He P","Lin K","Xu X","Feng S","Hu R","Lin M","Lan J","Ren X","Qu C","Yu M","Zhu Y","Tang A","Fu X","Millwood IY","Fu Z","Han X","Qin Y","Gou H","Pang Z","Qu F","Cheng X","Zhao X","Fan L","Cheng L","An Y","Wei L","Zhou J","Zhou L","Tian H","Zhou S","Zang Y","Xing X","You S","China Kadoorie Biobank Collaborative Group","Cui X","Gua C","Kartsonaki C","Zhou Y","Chang X","Lv J","Clarke J","Yu C","Tian X","Cao Y","Qin H","Clarke C","Lv S","Barnard M","Millwood I","Rahmati M","Zhu T","Du P","Kakkoura M","Wu M","Du R","Dong Y","Wang B","Wang C","Lu Y","Lu Z","Wang D","Clarke R","Chan KH","Du X","Schmidt D","Wang H","Dong Q","Wang J","Wang L","Wu Z","Gilbert S","Chen Z","Sun Q","Wang S","Xie K","Wang T","Sun D","Wu S","Chen Y","Wang W","Chen X","Wang X","Sun H","Wang Y","Xie C","Dong C","Ou T","Wu X","Kang K","Liao Z","Li H","Chen N","Yang J","Chen Q","Chen P","Yang L","Yao P","Chen J","Kang Q","Li F","Chen L","Walters RG","Xia Q","Chen F","Sun W","Chen H","Sun X","Li L","Hui SJL","Kolhe K","Yang X","Gao R","Li X","Pei P","Li Y","Pozarickij A","Li S","Chen LZX","Du H","Jv N","Iona A","Liu H","Jiang J","Liu J","Ma S","Mohamed AE","Ma L","Liu L","Liu M","Stevens R","Mazidi M","Mao E","Peto R","Ding J","Feng C","Avery D","Hou W","Morris S","Liu Y","Liu Z","Zhai Y","Jiang W","Mao Y","Ji D","Bennett D","Fry H","Collins R","Nie Q","Yan S","Luo H","Duan H","Ning F","Stevens B","Zhang X","Boxall R","Tao R","Hou C","Liu C","Lam H","Pan L","Yin L","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.","description":"<h4>Background and objective</h4>Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.<h4>Methods</h4>Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome-wide association (GWAS) summary statistics of snoring and BMI from CKB (n = 100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891-25,892 cases, 142,336-168,186 controls). Single-variable and multivariable two-sample bi-directional Mendelian randomization (MR) analyses were perfor","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-11T04:55:23.079Z","creation":"2026-06-11T03:08:22.544Z"},"accession":"S-EPMC7617645","cross_references":{"pubmed":["39910910"],"doi":["10.1111/resp.14893"]}}