biostudies-literatureZhu YMinistry of Science and Technology of the People's Republic of ChinaCancer Research UKBritish Heart FoundationNoncommunicable Chronic Diseases-National Science and Technology Major ProjectKadoorie Charitable FoundationMinistry of Science and Technology of the People&apos;s Republic of ChinaMedical Research CouncilNational Natural Science Foundation of ChinaWellcome TrustNational Key Research and Development Program of ChinaKadoorie Charitable Foundation in Hong Kong346-358https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617645biostudies-literatureUnknown30(4)<h4>Background and objective</h4>Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.<h4>Methods</h4>Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome-wide association (GWAS) summary statistics of snoring and BMI from CKB (n = 100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891-25,892 cases, 142,336-168,186 controls). Single-variable and multivariable two-sample bi-directional Mendelian randomization (MR) analyses were perforRespirology (Carlton, Vic.)Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.PMC7617645088158/Z/09/Z2011BAI09B01104085C16077/A29186CH/1996001/9454202922/Z/16/Z202922MC_UU_12026/281941018C500/A1689621294616896MC_UU_00017/12016YFC0900500MC_U137686851A29186104085/Z/14/Z212946/Z/18/Z918463032023ZD05101000881588139054082388102821929008219290182192904Peng YFang KGuo ZHu YZhang JWright NZhang HZhang NShen DSu JZhang LZhang SWalters RRyder PJin DJin JYuan WJin LZheng XTurnbull IYuan MLan YXu JHe PLin KXu XFeng SHu RLin MLan JRen XQu CYu MZhu YTang AFu XMillwood IYFu ZHan XQin YGou HPang ZQu FCheng XZhao XFan LCheng LAn YWei LZhou JZhou LTian HZhou SZang YXing XYou SChina Kadoorie Biobank Collaborative GroupCui XGua CKartsonaki CZhou YChang XLv JClarke JYu CTian XCao YQin HClarke CLv SBarnard MMillwood IRahmati MZhu TDu PKakkoura MWu MDu RDong YWang BWang CLu YLu ZWang DClarke RChan KHDu XSchmidt DWang HDong QWang JWang LWu ZGilbert SChen ZSun QWang SXie KWang TSun DWu SChen YWang WChen XWang XSun HWang YXie CDong COu TWu XKang KLiao ZLi HChen NYang JChen QChen PYang LYao PChen JKang QLi FChen LWalters RGXia QChen FSun WChen HSun XLi LHui SJLKolhe KYang XGao RLi XPei PLi YPozarickij ALi SChen LZXDu HJv NIona ALiu HJiang JLiu JMa SMohamed AEMa LLiu LLiu MStevens RMazidi MMao EPeto RDing JFeng CAvery DHou WMorris SLiu YLiu ZZhai YJiang WMao YJi DBennett DFry HCollins RNie QYan SLuo HDuan HNing FStevens BZhang XBoxall RTao RHou CLiu CLam HPan LYin LLiu FfalseAssociations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.<h4>Background and objective</h4>Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.<h4>Methods</h4>Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome-wide association (GWAS) summary statistics of snoring and BMI from CKB (n = 100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891-25,892 cases, 142,336-168,186 controls). Single-variable and multivariable two-sample bi-directional Mendelian randomization (MR) analyses were perfor2025-01-01T00:00:00Z2025 Apr2026-06-11T04:55:23.079Z2026-06-11T03:08:22.544ZS-EPMC76176453991091010.1111/resp.14893