{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gandhivel VH"],"funding":["Department of Biotechnology, Ministry of Science and Technology (DBT)","DST | Science and Engineering Research Board","Department of Atomic Energy, Government of India","DST | Science and Engineering Research Board (SERB)","European Research Council","Department of Atomic Energy, Government of India (DAE)","Wellcome Trust","Department of Biotechnology, Ministry of Science and Technology"],"pagination":["790-807"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Paralogous variants of canonical histones guide accessibility to DNA and function as additional layers of genome regulation. Across eukaryotes, the mechanism of action and functional significance of several variants of core histones are well known except those of histone H4. Here we show that a variant of H4 (H4.V) expressing tissue-specifically among Oryza members mediated specific epigenetic changes contributing to salt tolerance. H4.V was incorporated into specific heterochromatic sites, where it blocked the deposition of active histone marks. Stress-dependent redistribution of H4.V enabled the incorporation of acetylated H4 lysine 5 (H4K5ac) in the gene bodies. The misexpression of H4.V led to defects in reproductive development and in mounting salt stress responses. H4.V formed homotypic nucleosomes and mediated these alterations by conferring distinct molecular properties to the nucleosomes, as seen with cryo electron microscopy structures and biochemical assays. These results reveal not only an H4 variant among plants but also a chromatin regulation that might have contributed to the adaptation of semi-aquatic Oryza members."],"journal":["Nature plants"],"pubmed_title":["An Oryza-specific histone H4 variant predisposes H4 lysine 5 acetylation to modulate salt stress responses."],"pmcid":["PMC7617672"],"funding_grant_id":["RTI 4006 (1303/3/2019/R&D-II/DAE/4749 dated 16.7.2020)","BT/IN/Swiss/47/JGK/2018-19","101054950","202811","CRG/2023/003849"],"pubmed_authors":["Gut F","Shivaprasad PV","Jha S","Jeyaprakash AA","Sotelo-Parrilla P","Harshith CY","Raju S","Gandhivel VH","Gireesh A","Berger F","Vinothkumar KR"],"additional_accession":[]},"is_claimable":false,"name":"An Oryza-specific histone H4 variant predisposes H4 lysine 5 acetylation to modulate salt stress responses.","description":"Paralogous variants of canonical histones guide accessibility to DNA and function as additional layers of genome regulation. Across eukaryotes, the mechanism of action and functional significance of several variants of core histones are well known except those of histone H4. Here we show that a variant of H4 (H4.V) expressing tissue-specifically among Oryza members mediated specific epigenetic changes contributing to salt tolerance. H4.V was incorporated into specific heterochromatic sites, where it blocked the deposition of active histone marks. Stress-dependent redistribution of H4.V enabled the incorporation of acetylated H4 lysine 5 (H4K5ac) in the gene bodies. The misexpression of H4.V led to defects in reproductive development and in mounting salt stress responses. H4.V formed homotypic nucleosomes and mediated these alterations by conferring distinct molecular properties to the nucleosomes, as seen with cryo electron microscopy structures and biochemical assays. These results reveal not only an H4 variant among plants but also a chromatin regulation that might have contributed to the adaptation of semi-aquatic Oryza members.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T05:23:24.505Z","creation":"2026-04-08T09:36:10.836Z"},"accession":"S-EPMC7617672","cross_references":{"pubmed":["40200022"],"doi":["10.1038/s41477-025-01974-2"]}}