{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Raza YN"],"funding":["Medical Research Council","Wellcome Trust"],"pubmed_abstract":["<h4>Background</h4>Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) are synthetic substances with long half-lives. Their presence is widespread and pervasive, and they are noted for their environmental persistence. Research has shown these chemicals to be associated with dyslipidaemia, although few studies have considered the long-term associations in the general population.<h4>Objectives</h4>The aim of this study was to consider the longitudinal and cross-sectional associations with lipid phenotypes.<h4>Methods</h4>We investigated the association of these chemicals with total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), and the total cholesterol: high-density lipoprotein ratio (TC:HDL), in a healthy unselected Br"],"journal":["Journal of exposure science & environmental epidemiology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617748"],"repository":["biostudies-literature"],"pubmed_title":["Longitudinal association of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure with lipid traits, in a healthy unselected population."],"pmcid":["PMC7617748"],"funding_grant_id":["MR/M004422/1"],"pubmed_authors":["Tomlinson M","Small KS","Moustafa JSE","Raza YN","Zhang X","Wang D","Bowyer RCE","Steves CJ","Falchi M","Menni C"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal association of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure with lipid traits, in a healthy unselected population.","description":"<h4>Background</h4>Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) are synthetic substances with long half-lives. Their presence is widespread and pervasive, and they are noted for their environmental persistence. Research has shown these chemicals to be associated with dyslipidaemia, although few studies have considered the long-term associations in the general population.<h4>Objectives</h4>The aim of this study was to consider the longitudinal and cross-sectional associations with lipid phenotypes.<h4>Methods</h4>We investigated the association of these chemicals with total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), and the total cholesterol: high-density lipoprotein ratio (TC:HDL), in a healthy unselected Br","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-03-31T11:07:40.203Z","creation":"2025-08-28T03:08:10.206Z"},"accession":"S-EPMC7617748","cross_references":{"pubmed":["40274963"],"doi":["10.1038/s41370-025-00773-3"]}}