{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yue J"],"funding":["Fujian Agriculture and Forestry University","Biotechnology and Biological Sciences Research Council","JSPS","Japan Society for the Promotion of Science"],"pagination":["2504-2514.e3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617815"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(12)"],"pubmed_abstract":["White campion (Silene latifolia, Caryophyllaceae) was the first vascular plant where sex chromosomes were discovered. This species is a classic model for studies on plant sex chromosomes due to presence of large, clearly distinguishable X and Y chromosomes that originated de novo about 11 million years ago (mya), but lack of genomic resources for this relatively large genome (∼2.8 Gb) remains a significant hurdle. Here we report S. latifolia female genome assembly integrated with sex-specific genetic maps of this species, focusing on sex chromosomes and their evolution. The analysis reveals a highly heterogeneous recombination landscape with strong reduction in recombination rate in the central parts of all chromosomes. Recombination on the X chromosome in female meiosis primarily occurs at the very ends, and over 85% of the X chromosome length is located in a massive (∼330 Mb) gene-poor, rarely recombining pericentromeric region (Xpr). The results indicate that the non-recombining region on the Y chromosome (NRY) initially evolved in a relatively small (∼15 Mb), actively recombining region at the end of the q-arm, possibly as a result of inversion on the nascent X chromosome. The NRY expanded about 6 mya via linkage between the Xpr and the sex-determining region, which may have been caused by expanding pericentromeric recombination suppression on the X chromosome. These findings shed light on the origin of sex chromosomes in S. latifolia and yield genomic resources to assist ongoing and future investigations into sex chromosome evolution."],"journal":["Current biology : CB"],"pubmed_title":["The origin and evolution of sex chromosomes, revealed by sequencing of the Silene latifolia female genome."],"pmcid":["PMC7617815"],"funding_grant_id":["JP21KK0128","JP22H05071","BB/P009808/1"],"pubmed_authors":["Xie W","Kan B","Kazama Y","Zhang X","Ming R","Zhang S","Xu X","Filatov DA","Yue J","Krasovec M"],"additional_accession":[]},"is_claimable":false,"name":"The origin and evolution of sex chromosomes, revealed by sequencing of the Silene latifolia female genome.","description":"White campion (Silene latifolia, Caryophyllaceae) was the first vascular plant where sex chromosomes were discovered. This species is a classic model for studies on plant sex chromosomes due to presence of large, clearly distinguishable X and Y chromosomes that originated de novo about 11 million years ago (mya), but lack of genomic resources for this relatively large genome (∼2.8 Gb) remains a significant hurdle. Here we report S. latifolia female genome assembly integrated with sex-specific genetic maps of this species, focusing on sex chromosomes and their evolution. The analysis reveals a highly heterogeneous recombination landscape with strong reduction in recombination rate in the central parts of all chromosomes. Recombination on the X chromosome in female meiosis primarily occurs at the very ends, and over 85% of the X chromosome length is located in a massive (∼330 Mb) gene-poor, rarely recombining pericentromeric region (Xpr). The results indicate that the non-recombining region on the Y chromosome (NRY) initially evolved in a relatively small (∼15 Mb), actively recombining region at the end of the q-arm, possibly as a result of inversion on the nascent X chromosome. The NRY expanded about 6 mya via linkage between the Xpr and the sex-determining region, which may have been caused by expanding pericentromeric recombination suppression on the X chromosome. These findings shed light on the origin of sex chromosomes in S. latifolia and yield genomic resources to assist ongoing and future investigations into sex chromosome evolution.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-06-01T12:02:47.398Z","creation":"2026-04-08T12:00:34.799Z"},"accession":"S-EPMC7617815","cross_references":{"pubmed":["37290443"],"doi":["10.1016/j.cub.2023.05.046"]}}