{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang X"],"funding":["China Scholarship Council","UK Research and Innovation Medical Research Council","Wellcome Trust"],"pagination":["115275"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(2)"],"pubmed_abstract":["Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. Their role, especially in sterile lung injury, is unknown. Using single-cell RNA sequencing (scRNA-seq), spectral analysis, and adoptive transfer in a bleomycin-induced sterile lung injury, we found that bleomycin activates murine pulmonary MAIT cells and is associated with a protective role against bleomycin-induced lung injury. MAIT cells drive the accumulation of type 1 conventional dendritic cells (cDC1s), limiting tissue damage in a DNGR-1-dependent manner. Human scRNA-seq data revealed that MAIT cells were activated, with increased cDC populations in idiopathic pulmonary fibrosis patients. Thus, MAIT cells enhance defense against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways."],"journal":["Cell reports"],"pubmed_title":["MAIT cells protect against sterile lung injury."],"pmcid":["PMC7617896"],"funding_grant_id":["104553/z/14/z","211050/Z/18/z","211050","MR/R015708/1","222426/Z/21/Z","222426"],"pubmed_authors":["Greco M","Li S","Zhang X","Hinks TSC","Klenerman P","Lason W"],"additional_accession":[]},"is_claimable":false,"name":"MAIT cells protect against sterile lung injury.","description":"Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. Their role, especially in sterile lung injury, is unknown. Using single-cell RNA sequencing (scRNA-seq), spectral analysis, and adoptive transfer in a bleomycin-induced sterile lung injury, we found that bleomycin activates murine pulmonary MAIT cells and is associated with a protective role against bleomycin-induced lung injury. MAIT cells drive the accumulation of type 1 conventional dendritic cells (cDC1s), limiting tissue damage in a DNGR-1-dependent manner. Human scRNA-seq data revealed that MAIT cells were activated, with increased cDC populations in idiopathic pulmonary fibrosis patients. Thus, MAIT cells enhance defense against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-03-27T16:17:42.186Z","creation":"2025-08-30T03:05:38.821Z"},"accession":"S-EPMC7617896","cross_references":{"pubmed":["39918959"],"doi":["10.1016/j.celrep.2025.115275"]}}