{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee CYC"],"funding":["Cancer Research Institute (CRI)","World Cancer Research Fund","Cancer Research UK","Worldwide Cancer Research","Gates Cambridge Trust","NIHR Cambridge Biomedical Research Centre (NIHR Cambridge BRC)","NIHR Cambridge Biomedical Research Centre","World Cancer Research Fund (WCRF)","Wellcome Trust","Cancer Research Institute"],"pagination":["1453-1470"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7617970"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(9)"],"pubmed_abstract":["Tumor-associated macrophages (TAM) are a universal feature of cancers but variably influence outcomes and treatment responses. In this study, we used a photoconvertible mouse to distinguish newly entering, monocyte-derived TAMs (mdTAM) that were enriched at the tumor core from resident-like TAMs that localized with fibroblasts at the tumor-normal interface. The mdTAM pool was highly dynamic and continually replenished by circulating monocytes. Upon tumor entry, these monocytes differentiated down two divergent fate trajectories distinguished by the expression of MHC class II. MHC-II+ mdTAMs were functionally distinct from MHC-II- mdTAMs, demonstrating increased capacity for endocytosis and Fc-gamma receptor-mediated phagocytosis, as well as proinflammatory cytokine production. Both mdTAM s"],"journal":["Cancer immunology research"],"pubmed_title":["In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade."],"pmcid":["PMC7617970"],"funding_grant_id":["ACRCelerate - A26825","220268/Z/20/Z","CRI3128","C54019/A27535","21-0073"],"pubmed_authors":["Hammond SA","Dovedi SJ","Withers DR","Kennedy BC","Vettore LA","Hasegawa T","Lee CYC","Tuong ZK","Dean I","Samarakoon Y","Sansom OJ","Li Z","Halim TYF","Carlesso G","Richoz N","Clatworthy MR","Gilroy KL"],"additional_accession":[]},"is_claimable":false,"name":"In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade.","description":"Tumor-associated macrophages (TAM) are a universal feature of cancers but variably influence outcomes and treatment responses. In this study, we used a photoconvertible mouse to distinguish newly entering, monocyte-derived TAMs (mdTAM) that were enriched at the tumor core from resident-like TAMs that localized with fibroblasts at the tumor-normal interface. The mdTAM pool was highly dynamic and continually replenished by circulating monocytes. Upon tumor entry, these monocytes differentiated down two divergent fate trajectories distinguished by the expression of MHC class II. MHC-II+ mdTAMs were functionally distinct from MHC-II- mdTAMs, demonstrating increased capacity for endocytosis and Fc-gamma receptor-mediated phagocytosis, as well as proinflammatory cytokine production. Both mdTAM s","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T21:45:10.952Z","creation":"2025-08-24T03:06:44.47Z"},"accession":"S-EPMC7617970","cross_references":{"pubmed":["40523200"],"doi":["10.1158/2326-6066.CIR-24-1233"]}}