{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Martin Garrido N"],"funding":["Royal Society","Wellcome Trust"],"pagination":["168713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618050"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["436(18)"],"pubmed_abstract":["Bacteriophage ΦKZ (PhiKZ) is the founding member of a family of giant bacterial viruses. It has potential as a therapeutic as its host, Pseudomonas aeruginosa, kills tens of thousands of people worldwide each year. ΦKZ infection is independent of the host transcriptional apparatus; the virus forms a \"nucleus\", producing a proteinaceous barrier around the ΦKZ genome that excludes the host immune systems. It expresses its own non-canonical multi-subunit non-virion RNA polymerase (nvRNAP), which is imported into its \"nucleus\" to transcribe viral genes. The ΦKZ nvRNAP is formed by four polypeptides representing homologues of the eubacterial β/β' subunits, and a fifth that is likely to have evolved from an ancestral homologue to σ-factor. We have resolved the structure of the ΦKZ nvRNAP initiat"],"journal":["Journal of molecular biology"],"pubmed_title":["Structure of the Bacteriophage PhiKZ Non-virion RNA Polymerase Transcribing from its Promoter p119L."],"pmcid":["PMC7618050"],"funding_grant_id":["206212/Z/17/A","206212","206212/Z/17/Z"],"pubmed_authors":["Yakunina M","de Martin Garrido N","Ramlaul K","Chen CS","Aylett CHS"],"additional_accession":[]},"is_claimable":false,"name":"Structure of the Bacteriophage PhiKZ Non-virion RNA Polymerase Transcribing from its Promoter p119L.","description":"Bacteriophage ΦKZ (PhiKZ) is the founding member of a family of giant bacterial viruses. It has potential as a therapeutic as its host, Pseudomonas aeruginosa, kills tens of thousands of people worldwide each year. ΦKZ infection is independent of the host transcriptional apparatus; the virus forms a \"nucleus\", producing a proteinaceous barrier around the ΦKZ genome that excludes the host immune systems. It expresses its own non-canonical multi-subunit non-virion RNA polymerase (nvRNAP), which is imported into its \"nucleus\" to transcribe viral genes. The ΦKZ nvRNAP is formed by four polypeptides representing homologues of the eubacterial β/β' subunits, and a fifth that is likely to have evolved from an ancestral homologue to σ-factor. We have resolved the structure of the ΦKZ nvRNAP initiat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-06T00:29:35.11Z","creation":"2026-05-24T03:11:38.305Z"},"accession":"S-EPMC7618050","cross_references":{"pubmed":["39029888"],"doi":["10.1016/j.jmb.2024.168713"]}}