biostudies-literatureHogea AWellcome TrustBiotechnology and Biological Sciences Research Council2103-2123https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618066biostudies-literatureUnknown599(7)<h4>Key points</h4>Rat somatosensory neurons express a junctional protein, junctophilin-4 (JPH4) JPH4 is necessary for the formation of store operated Ca²⁺ entry (SOCE) complex at the junctions between plasma membrane and endoplasmic reticulum in these neurons. Knockdown of JPH4 impairs endoplasmic reticulum Ca²⁺ store refill and junctional Ca²⁺ signalling in sensory neurons. In vivo knockdown of JPH4 in the dorsal root ganglion (DRG) sensory neurons significantly attenuated experimentally induced inflammatory pain in rats. Junctional nanodomain Ca²⁺ signalling maintained by JPH4 is an important contributor to the inflammatory pain mechanisms.<h4>Abstract</h4>Junctions of endoplasmic reticulum and plasma membrane (ER-PM junctions) form signallingThe Journal of physiologyJunctophilin-4 facilitates inflammatory signalling at plasma membrane-endoplasmic reticulum junctions in sensory neurons.PMC7618066BB/R003068/1BB/R02104X/1212302/Z/18/Z212302Liang CGamper NHuang DShah SHogea AJones FDu XHao HCarver CMfalseJunctophilin-4 facilitates inflammatory signalling at plasma membrane-endoplasmic reticulum junctions in sensory neurons.<h4>Key points</h4>Rat somatosensory neurons express a junctional protein, junctophilin-4 (JPH4) JPH4 is necessary for the formation of store operated Ca²⁺ entry (SOCE) complex at the junctions between plasma membrane and endoplasmic reticulum in these neurons. Knockdown of JPH4 impairs endoplasmic reticulum Ca²⁺ store refill and junctional Ca²⁺ signalling in sensory neurons. In vivo knockdown of JPH4 in the dorsal root ganglion (DRG) sensory neurons significantly attenuated experimentally induced inflammatory pain in rats. Junctional nanodomain Ca²⁺ signalling maintained by JPH4 is an important contributor to the inflammatory pain mechanisms.<h4>Abstract</h4>Junctions of endoplasmic reticulum and plasma membrane (ER-PM junctions) form signalling2021-01-01T00:00:00Z2021 Apr2026-05-18T03:09:20.776Z2026-05-18T03:07:13.805ZS-EPMC76180663356978110.1113/JP281331