{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pak TF"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["111666"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["577"],"pubmed_abstract":["Cell competition is a process in multicellular organisms where cells interact with their neighbours to determine a \"winner\" or \"loser\" status. The loser cells are eliminated through programmed cell death, leaving only the winner cells to populate the tissue. Cell competition is context-dependent; the same cell type can win or lose depending on the cell type it is competing against. Hence, winner/loser status is an emergent property. A key question in cell competition is: how do cells acquire their winner/loser status? In this paper, we propose a mathematical framework for studying the emergence of winner/loser status based on a set of quantitative criteria that distinguishes competitive from non-competitive outcomes. We apply this framework in a cell-based modelling context, to both highlight the crucial role of active cell death in cell competition and identify the factors that drive cell competition."],"journal":["Journal of theoretical biology"],"pubmed_title":["A mathematical framework for the emergence of winners and losers in cell competition."],"pmcid":["PMC7618079"],"funding_grant_id":["BB/M011224/1"],"pubmed_authors":["Pak TF","Pitt-Francis J","Baker RE"],"additional_accession":[]},"is_claimable":false,"name":"A mathematical framework for the emergence of winners and losers in cell competition.","description":"Cell competition is a process in multicellular organisms where cells interact with their neighbours to determine a \"winner\" or \"loser\" status. The loser cells are eliminated through programmed cell death, leaving only the winner cells to populate the tissue. Cell competition is context-dependent; the same cell type can win or lose depending on the cell type it is competing against. Hence, winner/loser status is an emergent property. A key question in cell competition is: how do cells acquire their winner/loser status? In this paper, we propose a mathematical framework for studying the emergence of winner/loser status based on a set of quantitative criteria that distinguishes competitive from non-competitive outcomes. We apply this framework in a cell-based modelling context, to both highlight the crucial role of active cell death in cell competition and identify the factors that drive cell competition.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-03T05:45:42.436Z","creation":"2026-04-25T03:14:38.702Z"},"accession":"S-EPMC7618079","cross_references":{"pubmed":["37956955"],"doi":["10.1016/j.jtbi.2023.111666"]}}