{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Mermet M"],"funding":["Medical Research Council","Société Française de Rhumatologie (SFR)","Wellcome Trust"],"pubmed_abstract":["Glucagon-like peptide-1 (GLP-1) has previously been shown to be indispensable for optimal bone strength by acting at the bone material level. However, it was not fully clear whether the effects of GLP-1 were mediated by direct or indirect actions on bone cells. In the present study, we were unable to demonstrate the expression of the GLP-1 receptor (GLP-1r) in bone tissue at the gene expression level using qPCR and in situ hybridization, or at the protein level. Furthermore, the peripheral administration of exendin-4, a specific GLP-1r agonist, in ovariectomized (OVX) BALB/c mice enhanced post-yield displacement (18%) and energy-to-fracture (24%), as well as bone volume/total volume (BV/TV) (11%), trabecular number (Tb.N) (6%), and collagen maturity (18%). These bone effects were still obs"],"journal":["American journal of physiology. Endocrinology and metabolism"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618104"],"repository":["biostudies-literature"],"pubmed_title":["The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice."],"pmcid":["PMC7618104"],"funding_grant_id":["MC_UU_12012/3","220271","220271/Z/20/Z","MRC_MC_UU_12012/3","2020-2650"],"pubmed_authors":["Mabilleau G","Cruciani-Guglielmacci C","Biggs E","Denom J","Mermet M","Wery M","Mieczkowska A","Reimann F","Gribble F","Magnan C"],"additional_accession":[]},"is_claimable":false,"name":"The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice.","description":"Glucagon-like peptide-1 (GLP-1) has previously been shown to be indispensable for optimal bone strength by acting at the bone material level. However, it was not fully clear whether the effects of GLP-1 were mediated by direct or indirect actions on bone cells. In the present study, we were unable to demonstrate the expression of the GLP-1 receptor (GLP-1r) in bone tissue at the gene expression level using qPCR and in situ hybridization, or at the protein level. Furthermore, the peripheral administration of exendin-4, a specific GLP-1r agonist, in ovariectomized (OVX) BALB/c mice enhanced post-yield displacement (18%) and energy-to-fracture (24%), as well as bone volume/total volume (BV/TV) (11%), trabecular number (Tb.N) (6%), and collagen maturity (18%). These bone effects were still obs","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-03T07:44:15.068Z","creation":"2026-04-26T03:09:46.942Z"},"accession":"S-EPMC7618104","cross_references":{"pubmed":["40789661"],"doi":["10.1152/ajpendo.00086.2025"]}}