{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Foskolou IP"],"funding":["Fundação para a Ciência e a Tecnologia","Allos Therapeutics","Karolinska Institutet","Wellcome Trust"],"pagination":["113013"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618115"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(9)"],"pubmed_abstract":["2-Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and R-2HG. Here, we investigate the differential roles of these two enantiomers in cluster of differentiation (CD)8<sup>+</sup> T cell biology, where we find they have highly divergent effects on proliferation, differentiation, and T cell function. We show here an analysis of structural determinants that likely underlie these differential effects on specific α-ketoglutarate (αKG)-dependent enzymes. Treatment of CD8<sup>+</sup> T cells with exogenous S-2HG, but not R-2HG, increased CD8<sup>+</sup> T cell fitness in vivo and enhanced anti-tumor activity. These data show that S-2HG and R-2HG should be considered as two distinct and important actors in the regulation of T cell function."],"journal":["Cell reports"],"pubmed_title":["The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function."],"pmcid":["PMC7618115"],"funding_grant_id":["092738","214283/Z/18/Z","SFRH/BD/115612/2016"],"pubmed_authors":["Johnson RS","Zandhuis ND","Cunha PP","Jorgensen C","Wolkers MC","Sanchez-Lopez E","Foskolou IP","Nathanael D","Nicolet BP","Guislain A","Palazon A","Kostidis S","Giera M","Tyrakis PA","Barbieri L","Bargiela D","Minogue EA"],"additional_accession":[]},"is_claimable":false,"name":"The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function.","description":"2-Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and R-2HG. Here, we investigate the differential roles of these two enantiomers in cluster of differentiation (CD)8<sup>+</sup> T cell biology, where we find they have highly divergent effects on proliferation, differentiation, and T cell function. We show here an analysis of structural determinants that likely underlie these differential effects on specific α-ketoglutarate (αKG)-dependent enzymes. Treatment of CD8<sup>+</sup> T cells with exogenous S-2HG, but not R-2HG, increased CD8<sup>+</sup> T cell fitness in vivo and enhanced anti-tumor activity. These data show that S-2HG and R-2HG should be considered as two distinct and important actors in the regulation of T cell function.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-04-08T18:33:16.129Z","creation":"2026-04-08T09:51:48.482Z"},"accession":"S-EPMC7618115","cross_references":{"pubmed":["37632752"],"doi":["10.1016/j.celrep.2023.113013"]}}