{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bernard C"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["eabm7466"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618116"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["378(6622)"],"pubmed_abstract":["Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV<sup>+</sup>) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type-specific and synapse type-specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV<sup>+</sup> int"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Cortical wiring by synapse type-specific control of local protein synthesis."],"pmcid":["PMC7618116"],"funding_grant_id":["MR/W006251/1","MR/N026063/1","202758","MR/S010785/1"],"pubmed_authors":["Oozeer F","Hamid F","Allison L","Selten M","Rico B","Sanalidou S","Hanusz-Godoy A","Russell M","Marin O","Exposito-Alonso D","Bernard C","Aguilera A","Maeso P","Fleck RA"],"additional_accession":[]},"is_claimable":false,"name":"Cortical wiring by synapse type-specific control of local protein synthesis.","description":"Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV<sup>+</sup>) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type-specific and synapse type-specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV<sup>+</sup> int","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-06-01T06:32:12.707Z","creation":"2026-04-08T09:56:26.786Z"},"accession":"S-EPMC7618116","cross_references":{"pubmed":["36423280"],"doi":["10.1126/science.abm7466"]}}