{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Corato E"],"funding":["European Research Council"],"pagination":["physrevapplied.23.024031"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618166"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(2)"],"pubmed_abstract":["High-acoustic-energy-density acoustofluidic devices are necessary to make this technology a viable option for clinical applications in the biomedical field. We present a mechanical interface that enables delivery of a high-amplitude acoustic field inside a fluid cavity by translating the vibrations from two large piezoelectric elements into a microfluidic chip. The study comprises both experimental characterization of a double-parabolic metallic acoustic waveguide and simulations of its working mechanism in two dimensions. We could focus 4.9-μm polystyrene particles at a flowrate of 5 ml/min, corresponding to an average retention time of 13.5 ms for particles in the actuated area. Moreover, we measured the acoustic energy density in the channel at stopped-flow condition, obtaining an average value of 1207 J<i>/</i>m<sup>3</sup> and a maximum value of 2977 J<i>/</i>m<sup>3</sup> with an input electrical power of 1.5 W. By comparing the simulation results with laser-Doppler vibrometer measurements, we confirmed that transverse sound waves play a significant role in the working mechanism of the double-parabolic structure, thus paving the way for further future optimization of the waveguide design."],"journal":["Physical review applied"],"pubmed_title":["High-energy-density acoustofluidic device using a double-parabolic ultrasonic transducer."],"pmcid":["PMC7618166"],"funding_grant_id":["852590"],"pubmed_authors":["Jakobsson O","Augustsson P","Qiu W","Corato E","Morita T"],"additional_accession":[]},"is_claimable":false,"name":"High-energy-density acoustofluidic device using a double-parabolic ultrasonic transducer.","description":"High-acoustic-energy-density acoustofluidic devices are necessary to make this technology a viable option for clinical applications in the biomedical field. We present a mechanical interface that enables delivery of a high-amplitude acoustic field inside a fluid cavity by translating the vibrations from two large piezoelectric elements into a microfluidic chip. The study comprises both experimental characterization of a double-parabolic metallic acoustic waveguide and simulations of its working mechanism in two dimensions. We could focus 4.9-μm polystyrene particles at a flowrate of 5 ml/min, corresponding to an average retention time of 13.5 ms for particles in the actuated area. Moreover, we measured the acoustic energy density in the channel at stopped-flow condition, obtaining an average value of 1207 J<i>/</i>m<sup>3</sup> and a maximum value of 2977 J<i>/</i>m<sup>3</sup> with an input electrical power of 1.5 W. By comparing the simulation results with laser-Doppler vibrometer measurements, we confirmed that transverse sound waves play a significant role in the working mechanism of the double-parabolic structure, thus paving the way for further future optimization of the waveguide design.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-03T20:34:28.523Z","creation":"2026-05-01T03:11:12.081Z"},"accession":"S-EPMC7618166","cross_references":{"pubmed":["41000268"],"doi":["10.1103/physrevapplied.23.024031"]}}