{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gomez de Las Heras MM"],"funding":["European Research Council"],"pagination":["eadv0985"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(110)"],"pubmed_abstract":["Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut barrier integrity and the implications of this deterioration for inflammaging, senescence, and health decline. Using the <i>Tfam</i><sup>fl/fl</sup><i>Cd4</i><sup>Cre</sup> mouse model, we found that T cell failure compromised gut immunity leading to a decrease in T follicular cells and regulatory T cells (T<sub>reg</sub> cells) and an accumulation of highly proinflammatory and cytotoxic T cells. These alterations were associated with intestinal barrier disruption and gut dysbiosis. Microbiota depletion or adoptive transfer of total CD4 T cells or a T<sub>reg</sub> cell-enriched pool prevented gut barrier dysfunction and mitigated premature inflammaging and senescence, ultimately enhancing the health span in this mouse model. Thus, a competent CD4 T cell compartment is critical to ensure healthier aging by promoting host-microbiota mutualism and gut barrier integrity."],"journal":["Science immunology"],"pubmed_title":["CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity."],"pmcid":["PMC7618201"],"funding_grant_id":["101044248"],"pubmed_authors":["Fernandez-Almeida A","Francos-Quijorna I","Aranda JF","Dias-Almeida J","Simo C","Nunez G","Delgado-Pulido S","Galvez-Castano MI","Gomez de Las Heras MM","Mittelbrunn M","Garcia-Canas V","Escrig-Larena JI","Perez-Manrique M","Soto-Heredero G","Gabande-Rodriguez E","Inohara N","Carrasco E","Blanco EM"],"additional_accession":[]},"is_claimable":false,"name":"CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity.","description":"Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut barrier integrity and the implications of this deterioration for inflammaging, senescence, and health decline. Using the <i>Tfam</i><sup>fl/fl</sup><i>Cd4</i><sup>Cre</sup> mouse model, we found that T cell failure compromised gut immunity leading to a decrease in T follicular cells and regulatory T cells (T<sub>reg</sub> cells) and an accumulation of highly proinflammatory and cytotoxic T cells. These alterations were associated with intestinal barrier disruption and gut dysbiosis. Microbiota depletion or adoptive transfer of total CD4 T cells or a T<sub>reg</sub> cell-enriched pool prevented gut barrier dysfunction and mitigated premature inflammaging and senescence, ultimately enhancing the health span in this mouse model. Thus, a competent CD4 T cell compartment is critical to ensure healthier aging by promoting host-microbiota mutualism and gut barrier integrity.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-04T04:49:23.278Z","creation":"2026-05-05T03:12:38.102Z"},"accession":"S-EPMC7618201","cross_references":{"pubmed":["40749035"],"doi":["10.1126/sciimmunol.adv0985"]}}