{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murphy L"],"funding":["Cancer Research UK","Medical Research Council"],"pagination":["eadp3971"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618233"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["389(6761)"],"pubmed_abstract":["Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in \"cell-free\" DNA in plasma (cfDNA). An excess of cfDNA is deleterious. Given their ability to internalize pathogen-derived nucleic acids, we hypothesized that platelets may also clear endogenous cfDNA. We found that, despite lacking a nucleus, platelets contained a repertoire of DNA fragments mapping across the nuclear genome. We detected fetal DNA in maternal platelets and cancer-derived DNA in platelets from patients with premalignant and cancerous lesions. As current liquid biopsy approaches utilize platelet-depleted plasma, important genetic information contained within platelets is being missed. This study establishes a physiological r"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA."],"pmcid":["PMC7618233"],"funding_grant_id":["RCCSCF-May24/100001","29034","EDDCPJT\\100003","MR/T04490X/1"],"pubmed_authors":["Gregory CD","Biswas S","O'Sullivan J","Leedham S","Etzioni Z","Desborough M","Kriaucionis S","Rimmer MP","Hitchcock IS","Jooss NJ","Khan AO","Mead AJ","Vatish M","Murphy L","Benlabiod C","Inchauspe J","Holland P","Shepherd E","Rees P","Schuster-Bockler B","Karali CS","Denly L","Chen L","Sousos N","Belnoue-Davis HL","Psaila B","Hughes JR","Li R","Murphy E","Nasreddin N","O'Neill E","Valenzano G","Koupenova M"],"additional_accession":[]},"is_claimable":false,"name":"Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.","description":"Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in \"cell-free\" DNA in plasma (cfDNA). An excess of cfDNA is deleterious. Given their ability to internalize pathogen-derived nucleic acids, we hypothesized that platelets may also clear endogenous cfDNA. We found that, despite lacking a nucleus, platelets contained a repertoire of DNA fragments mapping across the nuclear genome. We detected fetal DNA in maternal platelets and cancer-derived DNA in platelets from patients with premalignant and cancerous lesions. As current liquid biopsy approaches utilize platelet-depleted plasma, important genetic information contained within platelets is being missed. This study establishes a physiological r","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-04T08:52:28.447Z","creation":"2026-05-07T03:12:29.763Z"},"accession":"S-EPMC7618233","cross_references":{"pubmed":["40811534"],"doi":["10.1126/science.adp3971"]}}