{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barton A"],"funding":["Horizon 2020 Framework Programme","European Commission","Wellcome Trust"],"pagination":["67-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618281"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(2)"],"pubmed_abstract":["Locus-specific amplicon sequencing was used to HLA type 336 participants of Maasai ethnicity at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci. Participants were recruited from three study villages in North Tanzania, for the purpose of investigating risk factors for trachomatous scarring in children. Other than HLA-A, all loci significantly deviated from Hardy-Weinberg equilibrium, possibly due to high relatedness between individuals: 238 individuals shared a house with at least one another participant. The most frequent allele for each locus were A*68:02 (14.3 %), B*53:01 (8.4 %), C*06:02 (19.2 %), DRB1*13:02 (17.7 %), DQB1*02:01 (16.9 %) and DPB1*01:01 (15.7 %), while the most common inferred haplotype was A*68:02 ∼ B*18:01 ∼ C*07:04 ∼ DRB1*08:04 ∼ DQB1*04:02 ∼ DPB1*04:01 (1.3 %)."],"journal":["Human immunology"],"pubmed_title":["HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 allele frequencies of North Tanzanian Maasai."],"pmcid":["PMC7618281"],"funding_grant_id":["093368/Z/10/Z","093368","098481","733373","098481/Z/12/Z"],"pubmed_authors":["Mafuru E","Houghton J","Mtuy T","Payne T","Barton A","Harte A","Ramadhani A","Derrick T","Malissa A","Roberts CH","Pickering H","Holland MJ","Burton MJ","Massae P"],"additional_accession":[]},"is_claimable":false,"name":"HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 allele frequencies of North Tanzanian Maasai.","description":"Locus-specific amplicon sequencing was used to HLA type 336 participants of Maasai ethnicity at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci. Participants were recruited from three study villages in North Tanzania, for the purpose of investigating risk factors for trachomatous scarring in children. Other than HLA-A, all loci significantly deviated from Hardy-Weinberg equilibrium, possibly due to high relatedness between individuals: 238 individuals shared a house with at least one another participant. The most frequent allele for each locus were A*68:02 (14.3 %), B*53:01 (8.4 %), C*06:02 (19.2 %), DRB1*13:02 (17.7 %), DQB1*02:01 (16.9 %) and DPB1*01:01 (15.7 %), while the most common inferred haplotype was A*68:02 ∼ B*18:01 ∼ C*07:04 ∼ DRB1*08:04 ∼ DQB1*04:02 ∼ DPB1*04:01 (1.3 %).","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-10T03:23:22.659Z","creation":"2026-05-10T03:12:18.967Z"},"accession":"S-EPMC7618281","cross_references":{"pubmed":["36335052"],"doi":["10.1016/j.humimm.2022.10.008"]}}