{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang W"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["101488"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618329"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(11)"],"pubmed_abstract":["Ambient air pollutants are leading contributors to global mortality. Despite the well-established risks, most studies have relied on single-pollutant models in limited regions, leaving the combined effects and individual contributions of pollutants unclear, particularly across countries. Here, we integrate daily mortality and air pollutant (nitrogen dioxide [NO<sub>2</sub>], ozone [O<sub>3</sub>], fine particulate matter, and sulfur dioxide) data from 482 cities in 12 countries/territories from 1998 to 2021 to assess the joint mortality risks and identify the main contributing pollutant through an air quality health index of multi-pollutant constrained groupwise additive models (AQHI-Multi). AQHI-Multi outperformed commonly used air quality indices in capturing the overall mortality risks. O<sub>3</sub> and NO<sub>2</sub> were the leading contributors (accounting for over 70% across countries/territories), with O<sub>3</sub>'s share increasing slightly to moderately in most countries/territories. These findings highlight the need for developing air quality indices using advanced multi-pollutant models and the emerging global significance of targeted control of O<sub>3</sub> and NO<sub>2</sub>."],"journal":["One earth (Cambridge, Mass.)"],"pubmed_title":["Improved global air quality health index reveals ozone and nitrogen dioxide as main drivers of air-pollution-related acute mortality."],"pmcid":["PMC7618329"],"funding_grant_id":["MR/V034162/1"],"pubmed_authors":["Zhang J","Guo Y","Yu P","Masselot P","Sun Q","Madureira J","Yu W","Sera F","Tong S","Bell ML","Hashizume M","Xu R","Zhou S","Gaio V","Gasparrini A","Kan H","Yang Z","Breitner S","MCC Collaborative Research Network","Li S","Li T","Lavigne E","Huang W","Zhang Y","Guo YL"],"additional_accession":[]},"is_claimable":false,"name":"Improved global air quality health index reveals ozone and nitrogen dioxide as main drivers of air-pollution-related acute mortality.","description":"Ambient air pollutants are leading contributors to global mortality. Despite the well-established risks, most studies have relied on single-pollutant models in limited regions, leaving the combined effects and individual contributions of pollutants unclear, particularly across countries. Here, we integrate daily mortality and air pollutant (nitrogen dioxide [NO<sub>2</sub>], ozone [O<sub>3</sub>], fine particulate matter, and sulfur dioxide) data from 482 cities in 12 countries/territories from 1998 to 2021 to assess the joint mortality risks and identify the main contributing pollutant through an air quality health index of multi-pollutant constrained groupwise additive models (AQHI-Multi). AQHI-Multi outperformed commonly used air quality indices in capturing the overall mortality risks. O<sub>3</sub> and NO<sub>2</sub> were the leading contributors (accounting for over 70% across countries/territories), with O<sub>3</sub>'s share increasing slightly to moderately in most countries/territories. These findings highlight the need for developing air quality indices using advanced multi-pollutant models and the emerging global significance of targeted control of O<sub>3</sub> and NO<sub>2</sub>.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T13:58:02.531Z","creation":"2026-05-31T03:10:15.102Z"},"accession":"S-EPMC7618329","cross_references":{"pubmed":["41362416"],"doi":["10.1016/j.oneear.2025.101488"]}}