{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kunkler IH"],"funding":["Medical Research Council"],"pagination":["1771-1783"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618363"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["393(18)"],"pubmed_abstract":["<h4>Background</h4>The role of postmastectomy chest-wall irradiation in patients with breast cancer classified as pN1 (with involvement of one to three axillary nodes) or pN0 (pathologically node negative) with additional risk factors is uncertain.<h4>Methods</h4>In this international, phase 3, randomized trial, we evaluated the omission of chest-wall irradiation in women with \"intermediate-risk\" breast cancer - defined as cancer that was stage pT1N1, pT2N1, or pT3N0 or stage pT2N0 with a histologic grade of 3, lymphovascular invasion, or both (tumor size: T1, ≤2 cm; T2, >2 cm to 5 cm; or T3, >5 cm) - that was treated with mastectomy, an axillary procedure, and systemic therapy. Patients were assigned to undergo chest-wall irradiation (40 to 50 Gy; the irradiation group) or not to undergo "],"journal":["The New England journal of medicine"],"pubmed_title":["Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer."],"pmcid":["PMC7618363"],"funding_grant_id":["G0400170 grant ID 69733","G0400170"],"pubmed_authors":["Velikova G","SUPREMO Trial Investigators","Hatcher O","Shah N","Syndikus I","Wright K","Bartlett JMS","Robson P","Sadler G","Whipp E","Anandadas C","Bedi C","Jyothirmayi R","Ritchie D","Hurkmans C","Rolles M","Evan R","Maclennan M","Simmonds P","Riddle K","van Tienhoven G","Gaffney C","Bundred N","Bahl A","McCormick G","Sham SY","Down S","Dhadda A","Kendall A","Welch R","Chittalia A","Mahtab N","Williams LJ","Storey N","DeSilva-Minor S","Neal A","Lawless S","Hatton M","Lawton P","Russell NS","McLennan M","McCarty H","Locke I","Lee D","Woodings P","O'Toole L","Westwell S","Kelly C","Sainsbury R","Macdonald E","Barthakur U","Ghosal N","Stockdale A","Hall A","Eichholz A","Bishop J","Brunt A","Chaudhuri A","Hicks J","Hignett S","Roe H","Taylor KJ","Wolstenholme V","Geropantas K","Lumsden G","Barraclough L","Blackman G","Clarke J","Brunt M","Sergenson N","Michalakis I","Roberts N","Upadhyay S","Varughese M","Sampson K","Goodman A","Brown A","Wells T","Sunil","Walji N","Thomas JS","Chakrabarti A","Haritakis M","Namini S","Thompson E","Kumar S","Thorp N","Evans R","Wang S","Fraser J","Masinghe S","Alhasso A","Griffin M","Persic M","Hogg M","Dunlop J","Vaidya J","Sherwin L","Hanby AM","Soe W","MacGregor C","Sharma R","Churn M","Hennessy A","Misra V","Branson T","Li Y","Dunn G","Jones J","Fernando I","Crellin P","McEleney T","Hamilton C","Brazil L","Bayman N","Canney P","Bowen J","Iqbal N","Johnson K","Dixon JM","Loncaster J","Danwata F","Westenberg H","Quigley M","Cameron D","Atkinson C","Beresford M","Mukesh MB","Mithal N","Forrest J","Barrett-Lee P","Thandar H","Williamson D","Magee B","Kunkler IH","Verghese ET","Lewanski C","Cleator S","Hadaki M","Raj S","Venables K","Piper T","Marshall J","Chapman H","Milanovic D","Grieve R","Harris S","Riddle P","Bliss P","Muturi F","Yuille F","Allerton R","Gahir D","Burns J","Lim C","Sripadam R","Anderson N","Khan M","Stevens A","Chua B","Brown J","Aird E","Lupton S","Skailes G","Needleman S","Malik Z"],"additional_accession":[]},"is_claimable":false,"name":"Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer.","description":"<h4>Background</h4>The role of postmastectomy chest-wall irradiation in patients with breast cancer classified as pN1 (with involvement of one to three axillary nodes) or pN0 (pathologically node negative) with additional risk factors is uncertain.<h4>Methods</h4>In this international, phase 3, randomized trial, we evaluated the omission of chest-wall irradiation in women with \"intermediate-risk\" breast cancer - defined as cancer that was stage pT1N1, pT2N1, or pT3N0 or stage pT2N0 with a histologic grade of 3, lymphovascular invasion, or both (tumor size: T1, ≤2 cm; T2, >2 cm to 5 cm; or T3, >5 cm) - that was treated with mastectomy, an axillary procedure, and systemic therapy. Patients were assigned to undergo chest-wall irradiation (40 to 50 Gy; the irradiation group) or not to undergo ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T16:36:24.67Z","creation":"2026-05-18T03:13:21.387Z"},"accession":"S-EPMC7618363","cross_references":{"pubmed":["41191939"],"doi":["10.1056/NEJMoa2412225"]}}