{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Villa-Hernandez S"],"funding":["Wellcome Trust"],"pagination":["15-29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618384"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["129"],"pubmed_abstract":["Neuropathic pain is a particularly intractable type of chronic pain that can result from physical nerve damage due to surgery or entrapment. Here, we present data which suggest that a particular subclass of fibroblast and mural cells may be implicated in the sensory neuron dysfunction that is characteristic of this pain state. In a mouse model of traumatic painful neuropathy, we used cell sorting, nerve tissue clearing and RNA sequencing to study stromal cells. With cell sorting (n = 4 mouse nerves) and tissue clearing (n = 5), we show that fibroblasts and mural cells positive for the platelet-derived growth factor receptor beta (Pdgfrb) gene are increased in number for at least two months post-nerve damage. Moreover, single cell RNA sequencing data (n = 4) from our own lab and those of th"],"journal":["Brain, behavior, and immunity"],"pubmed_title":["A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain?"],"pmcid":["PMC7618384"],"funding_grant_id":["224257/Z/21/Z","218452/Z/19/Z","224257","WT098051"],"pubmed_authors":["Li Y","Davis H","Taams LS","Villa-Hernandez S","Walker JV","Zebochin I","Shimizu F","Denk F","Hore Z","Fedele L","Kanda T"],"additional_accession":[]},"is_claimable":false,"name":"A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain?","description":"Neuropathic pain is a particularly intractable type of chronic pain that can result from physical nerve damage due to surgery or entrapment. Here, we present data which suggest that a particular subclass of fibroblast and mural cells may be implicated in the sensory neuron dysfunction that is characteristic of this pain state. In a mouse model of traumatic painful neuropathy, we used cell sorting, nerve tissue clearing and RNA sequencing to study stromal cells. With cell sorting (n = 4 mouse nerves) and tissue clearing (n = 5), we show that fibroblasts and mural cells positive for the platelet-derived growth factor receptor beta (Pdgfrb) gene are increased in number for at least two months post-nerve damage. Moreover, single cell RNA sequencing data (n = 4) from our own lab and those of th","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-06T03:19:15.247Z","creation":"2026-06-06T03:07:08.905Z"},"accession":"S-EPMC7618384","cross_references":{"pubmed":["40381746"],"doi":["10.1016/j.bbi.2025.05.012"]}}