biostudies-literatureKotronias RABritish Heart FoundationNIHR Oxford Biomedical Research Centre572-585https://www.ebi.ac.uk/biostudies/studies/S-EPMC7618422biostudies-literatureUnknown18(5)<h4>Background</h4>Clinical guidelines do not recommend coronary computed tomographic angiography (CTA) in elderly patients or in the presence of heavy coronary calcification. Photon-counting coronary computed tomographic angiography (PCCTA) introduces ultrahigh in-plane resolution and multienergy imaging, but the ability of this technology to overcome these limitations is unclear.<h4>Objectives</h4>The authors evaluate the ability of PCCTA to quantitatively assess coronary luminal stenosis in the presence and absence of calcification, comparing both the ultrahigh-resolution (UHR)-PCCTA and the multienergy standard-resolution (SR)-PCCTA with the criterion-standard 3-dimensional invasive quantitative coronary angiography (3D QCA).<h4>Methods</h4>The authors included 100 patients who had botJACC. Cardiovascular imagingBenchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis: Implications for Severely Calcified Coronaries.PMC7618422CH/F/21/90009FS/CRTF/23/24460Denton JKasongo MDawkins SHudson BRodrigues JHatem SBanning AHalborg TTavildari ATaylor CScreaton NKelion ABeer MChan KOxAMI and ORFAN InvestigatorsBradlow WFigtree GMehta NNFan LJRajani RPontone GBenetos GGuglielmo MShantouf RAntonopoulos ASHuck DKondo HKunadian VLin WHQin WChoudhury RPetersen SEAntoniades CKoo BKThomas SConnolly DLDweck MRBenedetti GCahill TJDeshpande AKharbanda RKMun MSGersh BJSantos BSSabharwal NMavrogiannis MCMittal TKAnthony SDai NNewby DEDangas GHudson Gde Maria GLRodriguez-Granillo GARao PPreston RLGe JGrenfell RKotronias RASchmitt MVilic DBajaj ADarby DMaurovich-Horvat PDanad ITousoulis DPortolan LKingham LMathers CLopez-Jimenez FMirsadraee SXie CAljazzaf HGraby JKietselaer BFairbairn TAGottlieb IHoldsworth DABerry CMarwan MLawday DDe Bosscher RFarrall RPugliese FSharma VBanning APRaisi-Estabragh ZNeves MFKotanidis CLangrish JPSerfaty FChannon KMBenedek TTakahashi NLedesma CSelvanayagam JWalsh JNeubauer SRose ADas IRedheuil ALucking AJHe GWfalseBenchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis: Implications for Severely Calcified Coronaries.<h4>Background</h4>Clinical guidelines do not recommend coronary computed tomographic angiography (CTA) in elderly patients or in the presence of heavy coronary calcification. Photon-counting coronary computed tomographic angiography (PCCTA) introduces ultrahigh in-plane resolution and multienergy imaging, but the ability of this technology to overcome these limitations is unclear.<h4>Objectives</h4>The authors evaluate the ability of PCCTA to quantitatively assess coronary luminal stenosis in the presence and absence of calcification, comparing both the ultrahigh-resolution (UHR)-PCCTA and the multienergy standard-resolution (SR)-PCCTA with the criterion-standard 3-dimensional invasive quantitative coronary angiography (3D QCA).<h4>Methods</h4>The authors included 100 patients who had bot2025-01-01T00:00:00Z2025 May2026-05-22T03:24:27.749Z2026-05-22T03:15:50.955ZS-EPMC76184223998550610.1016/j.jcmg.2024.11.005