biostudies-literatureUnknown15(11)Rodriguez-Lobato LG<h4>Background</h4>Autologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. However, despite the use of prophylactic antibiotics, neutropenic fever (NF) and hospital readmissions continue to pose as the most important limitations in the outpatient setting. It is possible that the febrile episodes may have a non-infectious etiology, and engraftment syndrome could play a more significant role. The aim of this study was to analyze the impact of both G-CSF withdrawal and the addition of primary prophylaxis with corticosteroids after ASCT.<h4>Methods</h4>Between January 2002 and August 2018, 111 MM patients conditioned with melphalan were managed at-home begPloS onee0241778https://www.ebi.ac.uk/biostudies/studies/S-EPMC7641449biostudies-literatureThe avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever.PMC7641449Castano-Diez SMartinez-Roca AGutierrez-Garcia GSegura SCarreras ECibeira MTRosinol LMoreno-Castano ABGallego CBlade JPalomino-Mosquera ALozano EPalomo MFernandez de Larrea CDiaz-Ricart MSuarez-Lledo MLozano MRovira MUrbano-Ispizua APedraza ACid JHernando AMarin PFernandez-Aviles FMartinez CRodriguez-Lobato LGfalseThe avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever.<h4>Background</h4>Autologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. However, despite the use of prophylactic antibiotics, neutropenic fever (NF) and hospital readmissions continue to pose as the most important limitations in the outpatient setting. It is possible that the febrile episodes may have a non-infectious etiology, and engraftment syndrome could play a more significant role. The aim of this study was to analyze the impact of both G-CSF withdrawal and the addition of primary prophylaxis with corticosteroids after ASCT.<h4>Methods</h4>Between January 2002 and August 2018, 111 MM patients conditioned with melphalan were managed at-home beg2020-01-01T00:00:00Z20202026-07-16T05:29:40.12Z2020-11-22T09:51:02ZS-EPMC76414493314725710.1371/journal.pone.0241778