biostudies-literatureTyson MDAHRQ HHSNCI NIH HHS26-33https://www.ebi.ac.uk/biostudies/studies/S-EPMC7643873biostudies-literatureUnknown74(1)<h4>Background</h4>Whether prostate cancer severity modifies patient-reported functional outcomes after radical prostatectomy (RP) or external beam radiotherapy (EBRT) for localized cancer is unknown.<h4>Objective</h4>The purpose of this study was to determine whether differences in predicted function over time between RP and EBRT varied by risk group.<h4>Design, setting, and participants</h4>The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a prospective, population-based, observational study that enrolled men with localized prostate cancer in 2011-2012. Among 2117 CEASAR participants who underwent RP or EBRT, 817 had low-risk, 902 intermediate-risk, and 398 high-risk disease.<h4>Outcome measurements and statistical analysis</h4>Patient-reported, disease-spEuropean urologyEffect of Prostate Cancer Severity on Functional Outcomes After Localized Treatment: Comparative Effectiveness Analysis of Surgery and Radiation Study Results.PMC7643873R01 HS019356R01 HS022640T32 CA106183Hashibe MKoyama TConwill RCooperberg MRPaddock LEGoodman MTyson MDGreenfield SLee DHamilton ASResnick MJWu XCStroup AHoffman KEBarocas DAChen VMcCollum DPenson DFfalseEffect of Prostate Cancer Severity on Functional Outcomes After Localized Treatment: Comparative Effectiveness Analysis of Surgery and Radiation Study Results.<h4>Background</h4>Whether prostate cancer severity modifies patient-reported functional outcomes after radical prostatectomy (RP) or external beam radiotherapy (EBRT) for localized cancer is unknown.<h4>Objective</h4>The purpose of this study was to determine whether differences in predicted function over time between RP and EBRT varied by risk group.<h4>Design, setting, and participants</h4>The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a prospective, population-based, observational study that enrolled men with localized prostate cancer in 2011-2012. Among 2117 CEASAR participants who underwent RP or EBRT, 817 had low-risk, 902 intermediate-risk, and 398 high-risk disease.<h4>Outcome measurements and statistical analysis</h4>Patient-reported, disease-sp2018-01-01T00:00:00Z2018 Jul2025-04-04T01:37:17.394Z2020-11-08T09:44:52ZS-EPMC76438732950145110.1016/j.eururo.2018.02.012