{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Q"],"funding":["Key Laboratory of Myocardial Ischemia, Ministry of Education","National Natural Science Foundation of China","Harbin Medical University","National Key Research and Development Program of China","Ministry of Education of the People's Republic of China"],"pagination":["2503-2518"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7646215"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(11)"],"pubmed_abstract":["Dendritic cells (DCs) can orchestrate either immunogenic or tolerogenic responses to relay information on the functional state. Emerging studies indicate that circular RNAs (circRNAs) are involved in immunity; however, it remains unclear whether they govern DC development and function at the transcriptional level. In this study, we identified a central role for a novel circRNA, circSnx5, in modulating DC-driven immunity and tolerance. Ectopic circSnx5 suppresses DC activation and promotes the development of tolerogenic functions of DCs, while circSnx5 knockdown promotes their activation and inflammatory phenotype. Mechanistically, circSnx5 can act as a miR-544 sponge to attenuate miRNA-mediated target depression on suppressor of cytokine signaling 1 (SOCS1) and inhibit nuclear translocatio"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pubmed_title":["Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation."],"pmcid":["PMC7646215"],"funding_grant_id":["81972143","81670459","YJSSJCX2018-66HYD","2016YFC1301100","kycx2018-01","KF201829","KF201816"],"pubmed_authors":["Tian J","Wu J","Chen Q","Zheng Y","Zhang H","Tong Z","Zhang M","Wang N","E M","Sun P","Yu B","Li T","Wang W","Mang G"],"additional_accession":[]},"is_claimable":false,"name":"Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation.","description":"Dendritic cells (DCs) can orchestrate either immunogenic or tolerogenic responses to relay information on the functional state. Emerging studies indicate that circular RNAs (circRNAs) are involved in immunity; however, it remains unclear whether they govern DC development and function at the transcriptional level. In this study, we identified a central role for a novel circRNA, circSnx5, in modulating DC-driven immunity and tolerance. Ectopic circSnx5 suppresses DC activation and promotes the development of tolerogenic functions of DCs, while circSnx5 knockdown promotes their activation and inflammatory phenotype. Mechanistically, circSnx5 can act as a miR-544 sponge to attenuate miRNA-mediated target depression on suppressor of cytokine signaling 1 (SOCS1) and inhibit nuclear translocatio","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-06-01T01:55:43.401Z","creation":"2025-06-01T01:55:43.401Z"},"accession":"S-EPMC7646215","cross_references":{"pubmed":["32681834"],"doi":["10.1016/j.ymthe.2020.07.001"]}}