{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Tan J"],"pubmed_abstract":["<b>Background:</b> This study was aimed at investigating the clinical significance and curative effect of global glomerulosclerosis (GS) and segmental glomerulosclerosis (S) in adult-onset IgA vasculitis with nephritis (IgAV-N) patients since there was no consensus pathological grading method for adult IgAV-N. <b>Methods:</b> A total of 188 biopsy-proven IgAV-N patients were prospectively identified. Patients were separately assigned to GS0/GS1/GS2 group and S0/S1/S2 based on the scores of global glomerulosclerosis and segmental glomerulosclerosis (0% /0-15% />15%, respectively). <b>Results:</b> GS0, GS1, and GS2 occurred in 56.4, 29.2, and 14.4% of the adult-onset IgAV-N, respectively. Patients in GS2 group tended to have the most serious renal deterioration and the highest levels of bloo"],"journal":["Frontiers in medicine"],"pagination":["588031"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7646400"],"repository":["biostudies-literature"],"pubmed_title":["Global Glomerulosclerosis and Segmental Glomerulosclerosis Could Serve as Effective Markers for Prognosis and Treatment of IgA Vasculitis With Nephritis."],"pmcid":["PMC7646400"],"pubmed_authors":["Tan L","Tarun P","Jiang Z","Tan J","Qin W","Zhong Z","Pei G","Tang Y","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Global Glomerulosclerosis and Segmental Glomerulosclerosis Could Serve as Effective Markers for Prognosis and Treatment of IgA Vasculitis With Nephritis.","description":"<b>Background:</b> This study was aimed at investigating the clinical significance and curative effect of global glomerulosclerosis (GS) and segmental glomerulosclerosis (S) in adult-onset IgA vasculitis with nephritis (IgAV-N) patients since there was no consensus pathological grading method for adult IgAV-N. <b>Methods:</b> A total of 188 biopsy-proven IgAV-N patients were prospectively identified. Patients were separately assigned to GS0/GS1/GS2 group and S0/S1/S2 based on the scores of global glomerulosclerosis and segmental glomerulosclerosis (0% /0-15% />15%, respectively). <b>Results:</b> GS0, GS1, and GS2 occurred in 56.4, 29.2, and 14.4% of the adult-onset IgAV-N, respectively. Patients in GS2 group tended to have the most serious renal deterioration and the highest levels of bloo","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-21T19:03:34.059Z","creation":"2020-11-19T15:24:56Z"},"accession":"S-EPMC7646400","cross_references":{"pubmed":["33195349"],"doi":["10.3389/fmed.2020.588031"]}}