{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jadcherla SR"],"funding":["NCATS NIH HHS","NIDDK NIH HHS"],"pagination":["645-652"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7647955"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["89(3)"],"pubmed_abstract":["Objective
To test the hypothesis that a feeding bundle concurrent with acid suppression is superior to acid suppression alone in improving gastroesophageal reflux disease (GERD) attributed-symptom scores and feeding outcomes in neonatal ICU infants.Methods
Infants (N = 76) between 34 and 60 weeks' postmenstrual age with acid reflux index > 3% were randomly allocated to study (acid-suppressive therapy + feeding bundle) or conventional (acid-suppressive therapy only) arms for 4 weeks. Feeding bundle included: total fluid volume < 140 mL/kg/day, fed over 30 min in right lateral position, and supine postprandial position. Primary outcome was independent oral feeding and/or ≥6-point decrease in symptom score (I-GERQ-R). Secondary outcomes included growth (weight, length, head ci"],"journal":["Pediatric research"],"pubmed_title":["Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial."],"pmcid":["PMC7647955"],"funding_grant_id":["R01 DK068158","UL1 TR002733"],"pubmed_authors":["Di Lorenzo C","Osborn EK","Jadcherla SR","Gulati IK","Viswanathan S","Slaughter JL","Hasenstab KA","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial.","description":"Objective
To test the hypothesis that a feeding bundle concurrent with acid suppression is superior to acid suppression alone in improving gastroesophageal reflux disease (GERD) attributed-symptom scores and feeding outcomes in neonatal ICU infants.Methods
Infants (N = 76) between 34 and 60 weeks' postmenstrual age with acid reflux index > 3% were randomly allocated to study (acid-suppressive therapy + feeding bundle) or conventional (acid-suppressive therapy only) arms for 4 weeks. Feeding bundle included: total fluid volume < 140 mL/kg/day, fed over 30 min in right lateral position, and supine postprandial position. Primary outcome was independent oral feeding and/or ≥6-point decrease in symptom score (I-GERQ-R). Secondary outcomes included growth (weight, length, head ci","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-04-18T01:26:44.718Z","creation":"2022-02-09T14:47:10.931Z"},"accession":"S-EPMC7647955","cross_references":{"pubmed":["32380509"],"doi":["10.1038/s41390-020-0932-4"]}}