biostudies-literatureJadcherla SRNCATS NIH HHSNIDDK NIH HHS645-652https://www.ebi.ac.uk/biostudies/studies/S-EPMC7647955biostudies-literatureUnknown89(3)<h4>Objective</h4>To test the hypothesis that a feeding bundle concurrent with acid suppression is superior to acid suppression alone in improving gastroesophageal reflux disease (GERD) attributed-symptom scores and feeding outcomes in neonatal ICU infants.<h4>Methods</h4>Infants (N = 76) between 34 and 60 weeks' postmenstrual age with acid reflux index > 3% were randomly allocated to study (acid-suppressive therapy + feeding bundle) or conventional (acid-suppressive therapy only) arms for 4 weeks. Feeding bundle included: total fluid volume < 140 mL/kg/day, fed over 30 min in right lateral position, and supine postprandial position. Primary outcome was independent oral feeding and/or ≥6-point decrease in symptom score (I-GERQ-R). Secondary outcomes included growth (weight, length, head ciPediatric researchRole of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial.PMC7647955R01 DK068158UL1 TR002733Di Lorenzo COsborn EKJadcherla SRGulati IKViswanathan SSlaughter JLHasenstab KAWei LfalseRole of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial.<h4>Objective</h4>To test the hypothesis that a feeding bundle concurrent with acid suppression is superior to acid suppression alone in improving gastroesophageal reflux disease (GERD) attributed-symptom scores and feeding outcomes in neonatal ICU infants.<h4>Methods</h4>Infants (N = 76) between 34 and 60 weeks' postmenstrual age with acid reflux index > 3% were randomly allocated to study (acid-suppressive therapy + feeding bundle) or conventional (acid-suppressive therapy only) arms for 4 weeks. Feeding bundle included: total fluid volume < 140 mL/kg/day, fed over 30 min in right lateral position, and supine postprandial position. Primary outcome was independent oral feeding and/or ≥6-point decrease in symptom score (I-GERQ-R). Secondary outcomes included growth (weight, length, head ci2021-01-01T00:00:00Z2021 Feb2026-04-18T01:26:44.718Z2022-02-09T14:47:10.931ZS-EPMC76479553238050910.1038/s41390-020-0932-4