{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vorspan F"],"funding":["Agence Nationale de la Recherche","Agence Nationale de la Recherche (French National Research Agency)"],"pagination":["381"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7648099"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Motor disturbances strongly increase the burden of cocaine use disorder (CUDs). The objective of our translational study was to identify the genes and biological pathways underlying the tolerance to cocaine-induced motor effects. In a 5-day protocol measuring motor tolerance to cocaine in rats (N = 40), modeling the motor response to cocaine in patients, whole-genome RNA sequencing was conducted on the ventral and dorsal striatum to prioritize a genetic association study in 225 patients with severe CUD who underwent thorough phenotypic (cocaine-induced hyperlocomotion, CIH; and cocaine-induced stereotypies, CIS) and genotypic [571,000 polymorphisms (SNPs)] characterization. We provide a comprehensive description of the rat striatal transcriptomic response to cocaine in our paradigm. Repeat"],"journal":["Translational psychiatry"],"pubmed_title":["Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances."],"pmcid":["PMC7648099"],"funding_grant_id":["ANR-13-NEUR-0001-03","ANR-17-NEU3-0002-05"],"pubmed_authors":["Bellivier F","Icick R","Blugeon C","Marie-Claire C","Benturquia N","Firmo C","Bloch V","Megarbane B","Vorspan F","Courtin C","Mekdad N","Prince N","Laplanche JL","Pishalin D"],"additional_accession":[]},"is_claimable":false,"name":"Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances.","description":"Motor disturbances strongly increase the burden of cocaine use disorder (CUDs). The objective of our translational study was to identify the genes and biological pathways underlying the tolerance to cocaine-induced motor effects. In a 5-day protocol measuring motor tolerance to cocaine in rats (N = 40), modeling the motor response to cocaine in patients, whole-genome RNA sequencing was conducted on the ventral and dorsal striatum to prioritize a genetic association study in 225 patients with severe CUD who underwent thorough phenotypic (cocaine-induced hyperlocomotion, CIH; and cocaine-induced stereotypies, CIS) and genotypic [571,000 polymorphisms (SNPs)] characterization. We provide a comprehensive description of the rat striatal transcriptomic response to cocaine in our paradigm. Repeat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-05-01T01:35:21.565Z","creation":"2020-11-19T13:37:26Z"},"accession":"S-EPMC7648099","cross_references":{"pubmed":["33159041"],"doi":["10.1038/s41398-020-01050-7"]}}