{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sutton G"],"funding":["IFCE (Institut Français du Cheval et de l’Equitation)","CENTAURE European project co-funded by Normandy County Council,"],"pagination":["E1160"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7650556"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(10)"],"pubmed_abstract":["Equid herpesvirus 1 is one of the most common viral pathogens in the horse population and is associated with respiratory disease, abortion and still-birth, neonatal death and neurological disease. A single point mutation in the DNA polymerase gene (ORF30: A2254G, N752D) has been widely associated with neuropathogenicity of strains, although this association has not been exclusive. This study describes the fortuitous isolation of a strain carrying a new genotype C<sub>2254</sub> (H<sub>752</sub>) from an outbreak in France that lasted several weeks in 2018 and involved 82 horses, two of which showed neurological signs of disease. The strain was characterised as U<sub>L</sub> clade 10 using the equid herpesvirus 1 (EHV-1) multi-locus sequence typing (MLST) classification but has not been ide"],"journal":["Viruses"],"pubmed_title":["Identification of a New Equid Herpesvirus 1 DNA Polymerase (ORF30) Genotype with the Isolation of a C<sub>2254</sub>/H<sub>752</sub> Strain in French Horses Showing no Major Impact on the Strain Behaviour."],"pmcid":["PMC7650556"],"funding_grant_id":["2017-008","European Union in the framework of the ERDF-ESF operationnal programme 2014-2020."],"pubmed_authors":["Deslis A","Pronost S","Marcillaud-Pitel C","Guitton E","Pleau A","Fortier C","Thieulent C","Hue ES","Sutton G","Paillot R"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a New Equid Herpesvirus 1 DNA Polymerase (ORF30) Genotype with the Isolation of a C<sub>2254</sub>/H<sub>752</sub> Strain in French Horses Showing no Major Impact on the Strain Behaviour.","description":"Equid herpesvirus 1 is one of the most common viral pathogens in the horse population and is associated with respiratory disease, abortion and still-birth, neonatal death and neurological disease. A single point mutation in the DNA polymerase gene (ORF30: A2254G, N752D) has been widely associated with neuropathogenicity of strains, although this association has not been exclusive. This study describes the fortuitous isolation of a strain carrying a new genotype C<sub>2254</sub> (H<sub>752</sub>) from an outbreak in France that lasted several weeks in 2018 and involved 82 horses, two of which showed neurological signs of disease. The strain was characterised as U<sub>L</sub> clade 10 using the equid herpesvirus 1 (EHV-1) multi-locus sequence typing (MLST) classification but has not been ide","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-04-08T02:25:22.715Z","creation":"2020-11-19T13:39:54Z"},"accession":"S-EPMC7650556","cross_references":{"pubmed":["33066315"],"doi":["10.3390/v12101160"]}}