biostudies-literatureSutton GIFCE (Institut Français du Cheval et de l’Equitation)CENTAURE European project co-funded by Normandy County Council,E1160https://www.ebi.ac.uk/biostudies/studies/S-EPMC7650556biostudies-literatureUnknown12(10)Equid herpesvirus 1 is one of the most common viral pathogens in the horse population and is associated with respiratory disease, abortion and still-birth, neonatal death and neurological disease. A single point mutation in the DNA polymerase gene (ORF30: A2254G, N752D) has been widely associated with neuropathogenicity of strains, although this association has not been exclusive. This study describes the fortuitous isolation of a strain carrying a new genotype C₂₂₅₄ (H₇₅₂) from an outbreak in France that lasted several weeks in 2018 and involved 82 horses, two of which showed neurological signs of disease. The strain was characterised as U_L clade 10 using the equid herpesvirus 1 (EHV-1) multi-locus sequence typing (MLST) classification but has not been ideVirusesIdentification of a New Equid Herpesvirus 1 DNA Polymerase (ORF30) Genotype with the Isolation of a C₂₂₅₄/H₇₅₂ Strain in French Horses Showing no Major Impact on the Strain Behaviour.PMC76505562017-008European Union in the framework of the ERDF-ESF operationnal programme 2014-2020.Deslis APronost SMarcillaud-Pitel CGuitton EPleau AFortier CThieulent CHue ESSutton GPaillot RfalseIdentification of a New Equid Herpesvirus 1 DNA Polymerase (ORF30) Genotype with the Isolation of a C₂₂₅₄/H₇₅₂ Strain in French Horses Showing no Major Impact on the Strain Behaviour.Equid herpesvirus 1 is one of the most common viral pathogens in the horse population and is associated with respiratory disease, abortion and still-birth, neonatal death and neurological disease. A single point mutation in the DNA polymerase gene (ORF30: A2254G, N752D) has been widely associated with neuropathogenicity of strains, although this association has not been exclusive. This study describes the fortuitous isolation of a strain carrying a new genotype C₂₂₅₄ (H₇₅₂) from an outbreak in France that lasted several weeks in 2018 and involved 82 horses, two of which showed neurological signs of disease. The strain was characterised as U_L clade 10 using the equid herpesvirus 1 (EHV-1) multi-locus sequence typing (MLST) classification but has not been ide2020-01-01T00:00:00Z2020 Oct2026-04-08T02:25:22.715Z2020-11-19T13:39:54ZS-EPMC76505563306631510.3390/v12101160