biostudies-literatureScarpa FRegione Autonoma della SardegnaE238https://www.ebi.ac.uk/biostudies/studies/S-EPMC7650684biostudies-literatureUnknown10(10)The fan mussel, <i>Pinna nobilis</i>, represents the largest bivalve endemic to the Mediterranean Sea. Since 2016, dramatic mass mortality of this species has been observed in several areas. The first surveys suggested that <i>Haplosporidium pinnae</i> (currently considered species-specific) was the main etiological agent, but recent studies have indicated that a multifactorial disease may be responsible for this phenomenon. In this study, we performed molecular diagnostic analyses on <i>P. nobilis</i>, <i>P. rudis</i>, and bivalve heterologous host species from the island of Sardinia to shed further light on the pathogens involved in the mass mortality. The results support the occurrence of a multifactorial disease and that <i>Mycobacterium</i> spp. and <i>H. pinnae</i> are not necessarilLife (Basel, Switzerland)Multiple Non-Species-Specific Pathogens Possibly Triggered the Mass Mortality in <i>Pinna nobilis</i>.PMC7650684Piano di Azione Regionale per la conservazione di Pinna nobilis (Allegato alla Delib.G.R. n. 61/39 del 18.12.2018)Prearo MGrech DCabana DHosseini SAtzori FSaba TAntuofermo ECossu PCasu MCadoni NScarpa FSechi LAMugetti DAzzena IAddis PPeletto SGazale VEsposito GMossa MASanna DCerruti FPinna SPasquini VfalseMultiple Non-Species-Specific Pathogens Possibly Triggered the Mass Mortality in <i>Pinna nobilis</i>.The fan mussel, <i>Pinna nobilis</i>, represents the largest bivalve endemic to the Mediterranean Sea. Since 2016, dramatic mass mortality of this species has been observed in several areas. The first surveys suggested that <i>Haplosporidium pinnae</i> (currently considered species-specific) was the main etiological agent, but recent studies have indicated that a multifactorial disease may be responsible for this phenomenon. In this study, we performed molecular diagnostic analyses on <i>P. nobilis</i>, <i>P. rudis</i>, and bivalve heterologous host species from the island of Sardinia to shed further light on the pathogens involved in the mass mortality. The results support the occurrence of a multifactorial disease and that <i>Mycobacterium</i> spp. and <i>H. pinnae</i> are not necessaril2020-01-01T00:00:00Z2020 Oct2026-04-08T02:28:03.742Z2020-11-19T11:33:03ZS-EPMC76506843306623010.3390/life10100238